ACE基因D/I多态性与动脉粥样硬化性肾病的关系探讨

Relationship between the Polymorphism of Angiotensin ConvertingEnzyme (ACE) Gene and Atherosclerotic Nephropathy

目的 进一步探讨ACE基因D/I多态性在中国汉族老年人动脉粥样硬化性肾病中的意义。方法 对 47例动脉粥样硬化性肾病患者和 87例对照者ACE基因D/I多态性进行分析。结果 ACE基因缺失型 (DD)在动脉粥样硬化性肾病患者中的发生率明显高于对照组 (分别为 42 6 %与 2 4 1% ,P <0 .0 5 ) ,而ACE基因插入型 (II)与缺失 /插入型 (DI)的发生率与对照无明显差别 (P >0 .0 5 )。结论 ACE基因D/I多态性与动脉粥样硬化性肾病的发生有一定的联系 ,它可能是动脉粥样硬化性肾病发生的危险因子之一。

Objective An insertion/deletion(I/D)polymorphism of the angiotensin converting enzyme(ACE)gene significantly plays a role in the development of atherosclerotic nephropathy. Method The ACE variants were determined by polymerase chain reaction(PCR)and the genotypes were classified as DD, DI and II. The ACE genotypes in 47 patients with atherosclerotic nephropathy and 87 control subjects. The microalbuminuria and renal hemodynamic parameters were studied in all groups. We retrospectively analyzed and compared the differences of clinical indicators, such as systolic pressure, diastole pressure and so on. Result There was significant difference in the DD genotype of ACE gene between atherosclerotic nephropathy and the control group(42.6% vs. 24.1%, P<0.05). There were no differences in the systolic pressure, the diastole pressure, the age of patients and original diseases. Conclusion These findings suggest that the DD genotype of ACE is associated with atherosclerotic nephropathy and that this polymorphism could be a potential genetic marker in atherosclerotic nephropathy.