血管内皮生长因子在贲门癌中的表达和临床意义

Expression and Clinical Significance of Vascular Endothelial Growth Factor in Gastric Cardia Cancer

目的 探讨贲门癌血管内皮生长因子 (VEGF)、血管生成与贲门癌临床病理特点的关系。方法 采用免疫组织化学技术 ,检测 35例贲门癌组织VEGF蛋白表达和微血管密度 (MVD)。分析VEGF和MVD的关系及其与贲门癌组织学分型、浸润深度、淋巴结转移和预后的关系。结果 VEGF阳性者MVD值显著高于阴性者 ,VEGF及MVD与贲门癌浸润深度 ,淋巴结转移密切相关 ,与组织学分型也有明显相关性。结论 VEGF与贲门癌的血管生成密切相关 ,对其生长和浸润转移起促进作用 ,VEGF可作为贲门癌生物学行为的指标之一。

Objective To approach the relationship between the Vascular endothelial growth factor[VEGF], the angiogenesis and the clinical pathological characteristics of gastric cardia carcinoma.Method Protein expressions of VEGF and VD in 35 patients with gastric cardia cancer were determined by immunohischemical staining. VEGF expressions were analyzed together with their relations to histologic type, depth of invasion, lymph node metastasis and distant metastasis. Result MVD was more notable in VEGF-positive esphageal carcinoma than in negative group. The protein expression of VEGF closely correlated with depth of invasion, lymph node metastasis. Their relations to the histologic types of gastric cardia cancer was also obvious. Conclusion VEGF is closely related to angiogenesis of esophageal carcinoma and promotes its growth, invasion and metastasis. The expression of VEGF is one of the biological behavioral indexes of grastric cardia carcinoma.