大肠癌P^(53)蛋白测定与临床生物学意义的相关研究

Expression and Clinical Significance of P^(53) Protein in Colorectal Cancer

目的 探讨P53 蛋白表达与大肠癌的关系及临床生物学意义。方法 采用免疫组织化学技术对 32例大肠癌组织及 16例正常大肠组织中的p53 蛋白的表达进行观察和比较。结果 P53 在正常大肠组织中表达阴性 ,P53 蛋白在大肠癌组织中表达阳性率为 5 3 13%。P53 蛋白在大肠癌组织中的表达与患者的性别、年龄、肿瘤大小、部位、大体分型、浸润深度、组织学类型、Ducks’分期及局部淋巴结转移无明显关系 (P >0 .0 5 )。P53 蛋白表达与大肠癌伴肝转移相关 (P <0 .0 5 )。结论 P53 蛋白在大肠癌组织中表达阳性 ,尤以伴肝转移者为著。p53 蛋白过度表达提示预后不良。

Objective To investigate the clinial significance of P 53 protein expression in patients with colorectal cancer.Method Using immunohistochemistry staining, We observed P 53 protein expression in 32 cases of colorectal cancer tissues and 16 cases of normal colorectal tissue. Result P 53 protein was negative in normal colorectal tissue. P 53 protein was positive in 17(53.13%)cases of colorectal cancer. The expression of P 53 protein had no apprent relation to the patients' sex, age, area of invasion, Duck's classfication, size of tumors, type of histopathology, lymphonodus metastases, etc(P>0.05). The over expression of P 53 protein was closely as sociated with the liver metastases(P<0.05). Conclusion P 53 protein was positive in colorectal cancer especially in patients with liver metastases. The abnormal expression of P 53 protien was associated with the poor prognosis.