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老年人EB病毒呈阳性弥漫性大B细胞淋巴瘤的研究进展 被引量:1

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摘要 在2008年版的世界卫生组织(WHO)分类中,老年人Epstein-Barr病毒(EBV)呈阳性弥漫性大B细胞淋巴瘤(DLBCL)作为新的疾病类型被单独列出.EBV呈阳性的DLBCL患者中,多数发病年龄大于50岁,无潜在免疫缺陷,临床上全身症状(B症状)明显,容易出现淋巴结外受累.该病临床过程呈高度侵袭性,对标准化疗方案反应差,患者总生存(OS)期短.笔者拟就目前对老年人EBV呈阳性DLBCL的发病机制、临床特征、治疗及预后等的最新研究进展进行综述.
出处 《国际输血及血液学杂志》 CAS 2014年第3期251-254,共4页 International Journal of Blood Transfusion and Hematology
基金 广西壮族自治区卫生厅课题(Z2013331)
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参考文献25

  • 1Oyama T,Ichimura K,Suzuki R,et al.Senile EBV+ B-cell lymphoproliferative disorders:a clinicopathologic study of 22 patients[J].Am J Surg Pathol,2003,27(1):16-26.
  • 2Nakamura S,Jaffe E,Swerdlow S.EBV positive diffuse large Bcell lymphoma of the elderly//Swerdlew SH,Campo E,Harris NL,et al.WHO classification of tumours of haematopoietic and lymphoid tissues[M].Lyon:IARC,2008:243-244.
  • 3Castillo JJ,Beltran BE,Miranda RN,et al.Epstein-Barr viruspositive diffuse large B-cell lymphoma of the elderly:what we know so far[J].Oncologist,2011,16(1):87-96.
  • 4Smith C,Khanna R.Epstein-Barr virus-associated malignancies:pathobiology and emerging therapeutic options[J].Microbiol Aust,2013,34(3):120-124.
  • 5Saha A,Robertson ES.Epstein-Barr virus-associated B-cell lymphomas:pathogenesis and clinical outcomes[J].Clin Cancer Res,2011,17(10):3056-3063.
  • 6De Oliveira D E,Ballon G,Cesarman E.NF-κB signaling modulation by EBV and KSHV[J].Trends Microbiol,2010,18(6):248-257.
  • 7Chen MR.Epstein-Barr virus,the immune system,and associated diseases[J].Front Microbiol,2011,2 (1):5.
  • 8Montes-Moreno S,Odqvist L,Diaz-Perez JA,et al.EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-κB activation[J].Modern Pathol,2012,25(7):968-982.
  • 9Adam P,Bonzheim I,Fend F,et al.Epstein-Barr virus-positive diffuse large B-cell lymphomas of the elderly[J].Adv Anat Pathol,2011,18(5):349-355.
  • 10Oyama T,Yamamoto K,Asano N,et al.Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group:A study of 96 patients[J].Clin Cancer Res,2007,13(17):5124-5132.

二级参考文献18

  • 1刘艳辉,庄恒国,林汉良,吴秋良,罗东兰,李丽,骆新兰.结节性淋巴细胞为主型霍奇金淋巴瘤和富于T细胞和(或)组织细胞的B细胞淋巴瘤的鉴别诊断[J].中华肿瘤杂志,2006,28(8):594-598. 被引量:4
  • 2Fisher R,Miller T,O'Connor O.Diffuse aggressive lymphoma//Broudy V,Berliner N,Larson R,et al.Hematology 2004.American Society of Hematology Education Program Book.Amsterdam:Elsevier Health Sciences,2004:221-236.
  • 3Oyama T,Ichimura K,Suzuki R,et al.Senile EBV + B-cell lymphoproliferative disorders:a clinicopathologic study of 22patients.Am J Surg Pathol,2003,27(1):16-26.
  • 4Nakamura S,Jaffe ES,Swerdlow SH.EBV positive diffuse large B-cell lymphoma//Swer dlow SH,Campo E,Harris NL,et al.World Health Organization classification of tumours.WHO classification of tumours of haematopietic and lymphoid tissues.Lyon:IARC,2008:243-244.
  • 5Oyama T,Yamamoto K,Asano N,et al.Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathloogic group:a study of 96 patients.Clin Cancer Res,2007,13(17):5124-5132.
  • 6Wong HH,Wang J.Epstein-Barr virus positive diffuse large B-cell lymphoma of the elderly.Leuk Lymphoma,2009,50 (3):335-340.
  • 7Asano N,Yamamoto K,Tamaru J,et al.Age-related EpsteinBarr virus (EBV)-associated B-cell lymphoproliferative disorders:comparison with EBV-positive classic Hodgkin lymphoma in elderly patients.Blood,2009,113(12):2629-2636.
  • 8Ouyang Q,Wagner WM,Walter S,et al.An age-related increase in the number of CD8 + T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness.Mech Ageing Dev,2003,124(4):477-485.
  • 9Yasunaga JI,Sakai T,Nosaka K,et al.Impaired production of na(i)ve T lymphocytes in human T-cell leukemia virus type I-infected individuals:its implications in the immunodeflcient state.Blood,2001,97(10):3177-3183.
  • 10Harada S,Kamata Y,Ishii Y,et al.Maintenance of serum immunoglobulin G antibodies to Epstein-Barr virus (EBV) nuclear antigen 2 in healthy individuals from different age groups in a Japanese population with a high childhood incidence of asymptomatic primary EBV infection.Clin Diagn Lab Immunol,2004,11(1):123-130.

共引文献21

同被引文献18

  • 1王春森,祝彪,王晓冬,张晋琳.奥沙利铂联合异环磷酰胺及泼尼松治疗老年人非霍奇金淋巴瘤的临床观察[J].中华血液学杂志,2007,28(10):700-701. 被引量:2
  • 2Mounier N, Briere J, Gisselhrecht C, et al. Rituximab plus CHOP (R-CHOP) overcome bel-2-assoeiated resistance to chemotherapy in elderly patients with Diffuse large B cell lymphoma (DLBCL) I-j]. Blood, 2003, 101 (10) : 4279-4284.
  • 3Olszewski AJ, Winer ES, Castillo JJ. Improved survival with rituximah-based chemoimmunotherapy in older patients with extranodal diffuse large B-cell lymphoma[J]. Leukemia Res, 2014, 38(8) : 866-873. DOI: 10. t016/j, leukres. 2014.04. 009.
  • 4Kikuehi M, Nakasone H, Akahoshi Y. Reduced-dose (two- thirds) R-CHOP chemotherapy for elderly patients with non- Hodgkin lymphoma[J]. J Chemotherapy, 2015, 27(2): 99-105. DOI: 10. 1179/1973947814Y. 0000000 219.
  • 5Aoki K, Takahashi T, Tabata S. Efficacy and tolerability of reduced-dose 21-day cycle rituximab and cyclophosphamide, doxorubicin, vincristine and prednisolone therapy for elderly patients with diff use large B-cell lymphoma [J ]. Leuk Lymphoma, 2013, 54 (11): 2441-2447. DOh 10. 3109/ 10428194. 2013. 780654.
  • 6Diem S, Ess S, Cerny T, et al. Diffuse large B-cell lymphoma in elderly patients: A retrospective analysis[J]. Eur J Intern Med, 2014, 25(6): 577-582. DOh 10.1016/j. ejim. 2014.05.001.
  • 7Morrison VA, Hamlin P, Soubeyran P. Approach to therapy of diffuse large B-cell lymphoma in the elderly: the International Society of Geriatric Oncology ( SIOG ) expert position commentary[J]. Ann Oncol, 2015, 26(6): 1058-1068.
  • 8Jung SH, Lee JJ, Kim WS. Weekly rituximab consolidation following four cycles of R-CHOP induction chemotherapy in very elderly patients with diffuse large B-celI lymphoma: Consortium for improving survival of lymphoma study (CISL) [J]. Eur J Hematol, 2014, 94(6): 504-510. DOI: 10.1111/ejh. 12459.
  • 9Avil~s A, Nambo MJ, Huerta-Guzmcin J. Rituximab as consolidation therapy did not improve outcome in patients with diffuse large b-cell lymphoma at complete response after dose- dense chemotherapy (CHOP-14) EJ~. Cancer Biother Radio, 2015, 30(3): 107-110. DOI: 10,1089/chr. 2014.1662.
  • 10Coiffer B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with Diffuse large B cell lymphoma[J]. N Engl J Med, 2002, 346 (4): 235-241. DOI: 10.1056/NEJMoa011795.

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