期刊文献+

治疗淋巴瘤相关药物所致肺损伤的研究进展 被引量:1

原文传递
导出
摘要 治疗淋巴瘤相关药物所致肺损伤(LTDIPI)可引起患者呼吸衰竭,严重者可致死亡,同时LTDIPI也是导致药物治疗淋巴瘤效果不佳的主要原因之一.其发病机制与药物对肺部的直接或间接的毒性作用、机体的免疫反应以及毛细血管通透性增加等因素有关.其病理学表现形式呈多样性,主要导致非特异性间质性肺炎、细支气管闭塞性炎症伴机化性肺炎、弥漫性肺损伤、肺纤维化、非心源性肺水肿以及变态反应性肺炎等.因LTDIPI的临床表现无特异性,且有致死的可能性,故诊断时除外其他非LTDIPI类肺部疾病十分重要,一旦诊断明确,应立即停用可能导致LTDIPI的相关抗淋巴瘤药物并及时予激素和其他相关药物治疗.
出处 《国际输血及血液学杂志》 CAS 2014年第3期255-259,共5页 International Journal of Blood Transfusion and Hematology
  • 相关文献

参考文献31

  • 1Matsuno O.Drug-induced interstitial lung disease:mechanisms and best diagnostic approaches[J].Respir Res,2012,13(1):39-48.
  • 2Zangari M,Fink LM,Elice F,et al.Thrombotic events in patients with cancer receiving antiangiogenesis agents[J].J Clin Oncol,2009,27(29):4865-4873.
  • 3Katsuya H,SuzumiyaJ,Sasaki H,et al.Addition ofrituximab to cyclophosphamide,doxorubicin,vincristine,and prednisolone therapy has a high risk of developing interstitialpneumonia in patients with non-Hodgkin lymphoma[J].Leuk Lymphoma,2009,50(11):1818-1823.
  • 4Obadina ET,Torrealba JM,Kanne JP.Acute pulmonary injury:high-resolution CT and histopathological spectrum[J].Br J Radiol,2013,86(1027):20120614.
  • 5Vargas HA,Hampson FA,Babar JL,et al.Imaging the lungs in patients treaed for lymphoma[J].Clin Radiol,2009,64 (11):1048-1055.
  • 6Chhabra P,Law AD,Suri V,et al.Methotrexate Induced lung injury in a patient with primary CNS lymphoma:a case report[J].Mediterr J Hematol Infect Dis,2012,4(1):e2012020.
  • 7Kim YJ,Song M,Ryu JC.Inflammation in methotrexateinduced pulmonary toxicity occurs via the p38MAPK pathway[J].Toxicology,2009,256(3):183-190.
  • 8Kim Y J,Song M,Ryu JC.Mechanisms underlying methotrexate-induced pulmonary toxicity[J].Expert Opin Drug Saf,2009,8(4):451-458.
  • 9Umemura S,Yamane H,Suwaki T,et al.Interstitial lung disease associated with gemcitabine treatment in patients with non-small-cell lung cancer and pancreatic cancer[J].J Cancer Res ClinOncol,2011,137(10):1469-1475.
  • 10Tamura M,Saraya T,Fujiwara M,et al.High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity,with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases[J].Oncologist,2013,18 (4):454-459.

同被引文献6

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部