阿司匹林对前列腺增生并急性尿潴留的影响

Efficacy of aspirin in the treatment of patients with benign prostatic hyperplasla combined with acute urine retention

目的观察阿司匹林治疗前列腺增生并急性尿潴留的临床疗效和安全性。方法选取沈阳市第一人民医院120例前列腺增生并急性尿潴留患者,随机分为阿司匹林组(60例)及对照组(60例)。阿司匹林组给予阿司匹林肠溶片联合非那雄胺、坦索罗欣治疗;对照组只给予非那雄胺和坦索罗欣治疗。随访6个月,观察和分析两组患者治疗前后前列腺大小、国际前列腺症状(IPSS)评分、最大尿流率、需手术治疗、急性尿潴留发生率及不良反应的情况。结果两组随访6个月后的前列腺大小、IPSS评分、最大尿流率与治疗前比较,差异均有统计学意义(均P<0.05)。随访6个月后,两组的前列腺大小、IPSS评分、最大尿流率比较差异无统计学意义(P>0.05)。阿司匹林组需手术治疗的患者比率及发生急性尿潴留率与对照组比较,差异统计学意义(x2=5.02、6.63,P<0.05)。两组均未见不良反应发生。结论阿司匹林预防能有效治疗前列腺增生并急性尿潴留,降低了前列腺增生患者手术治疗风险,且并发症少。

Objective To observe the clinical effect and safety on aspirin in the treatment of benign prostatic hyperplasla （BPH） combined with acute urine retention （AUR）. Methods 120 BPH patients with AUR of our hospital were selected and divided into aspirin treatment （60 cases） and control groups （60 cases）.Aspirin group was given finasteride, tamsulosin and aspirin, control group was given finasteride and tamsulosin.Volume of prostate.Follow up with 6 mouths, size of the prostate, IPSS scores, maximum urine flow rate, need surgery cases, cases of AUR and severe side effect related aspirin of two groups before and after treatment were observed. Results There were significant differences on the size of the prostate, IPSS scores, maximum urine flow rate of two groups after followed up for 6 months compared with before treatment （P0.05）. There were significant differences on the rate of need surgery and AUR rate of aspirin group compared with control group （x2=5.02, 6.63, P〈0.05）. There was no side effect in two groups. Conclusion Aspirin have a good effect in the treatment of BPH combined with AUR, and reduce the surgery risk of BPH patients with less adverse reaction.