埃索美拉唑治疗老年性胃溃疡的应用安全性分析

Analysis of application safety of esomeprazole in treatment of elderly patients with gastric ulcer

目的：对埃索美拉唑在老年性胃溃疡患者治疗中的安全性进行分析。方法在我院2012~2013年两年接收治疗的老年性胃溃疡患者中选取68例，分成两组，对照组患者采用奥美拉唑进行治疗，观察组患者采用埃索美拉唑进行治疗。对比分析其临床疗效。结果观察组患者的临床治疗总有效率为94.1%，对照组为73.5%，差异有统计学意义（P＜0.05）；观察组和对照组患者的Hp根除率分别为88.2%和67.6%，差异有统计学意义（P＜0.05）；观察组和对照组患者的不良反应发生率分别为8.8%和14.7%，差异有统计学意义（P＜0.05）。结论采用埃索美拉唑治疗老年性胃溃疡，有助于提高临床治疗有效率，降低不良反应的发生，具有较高安全性，值得推广。

Objective To analyze the safety of esomeprazole in the treatment of elderly patients with gastric ulcer. Methods Sixty-eight elderly patients with gastric ulcer treated in our hospital from 2012 to 2013 were divided into two groups. The control group received omeprazole treatment and the observation group received esomeprazole treatment. The clinical efficacy of the two groups was analyzed comparatively. Results The clinical total effective treatment rate of the observation group was 94.1% and that of the control group was only 73.5%, with significant difference （P〈0.05）;The Hp elimination rates of the observation group and the control group were 88.2%and 67.6%respectively, with significant difference （P〈0.05）; The incidences of adverse reactions of the observation group and the control group were 8.8%and 14.7%respectively, with significant difference （P〈0.05）. Conclusion The application of esomeprazole in the treatment of elderly patients with gastric ulcer is conducive to improving the clinical effective treatment rate and reducing the occurrence of adverse reactions and has high safety, thereby worthy of promotion.