阿米卡星与磷霉素治疗产KPC酶细菌的疗效观察

Therapeutic efficacy of amikacin combined with fosfomycin against bacteria producing KPC enzymes

目的了解阿米卡星、磷霉素联合使用和单独使用对产KPC酶细菌的疗效,为临床治疗产KPC酶细菌感染提供依据。方法收集2011年1月-2012年12月检测出产KPC酶20例住院患者资料,采用阿米卡星和磷霉素单用或联用治疗,并对其临床疗效和细菌学清除率进行回顾性统计分析。结果阿米卡星联用磷霉素的临床有效率和细菌学清除率均为71.4%,单用阿米卡星的临床有效率和细菌学清除率分别为57.1和28.6%,单用磷霉素的临床有效率和细菌学清除率分别为33.3%和16.7%。结论阿米卡星、磷霉素单用治疗产KPC酶细菌疗效不佳,但联用后可获得较好的疗效。

OBJECTIVE To analyze clinical therapeutic efficacy of amikacin combined with fosfomycin or amikacin/fosfomycin only against KPC-producing bacteria ,in order to provide evidence for the clinical therapy of KPC-producing bacteria infections .METHODS Totally 20 patients with KPC-producing bacteria infections were collecte d and treated with amikacin combined with fosfomycin or amikacin/fosfomycin only ,and the therapeutic effect and bacteria clearance rate were analyzed retrospectively .RESULTS The effective rate and the bacteria clearance rate of amikacin combination with fosfomycin were both 71 .43% ,while those of the method of amikacin only were 57 .1% and 28 .6% respectively . And those of the method of fosfomycin only were 33 .3% and 16 .7%respectively .CONCLUSION Amikacin combined with fosfomycin against KPC-producing bacteria could obtain well therapeutic effect ,which was much better than using amikacin or fosfomycin only .