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膦甲酸钠氯化钠治疗人乳头状瘤病毒感染宫颈炎的临床疗效 被引量:21

Clinical efficacy of foscarnet sodium and sodium chloride in treatment of cervicitis infected with persistent human papillomavirus
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摘要 目的探讨膦甲酸钠氯化钠治疗持续人乳头状瘤病毒(HPV)感染宫颈炎的临床疗效,探讨治疗新方法,提高HPV感染的转阴率,降低感染程度。方法选择2013年1月-2014年3月60例持续HPV感染宫颈炎患者作为研究对象,将其随机分为治疗组和对照组各30例;对照组给予干扰素α-2b栓,治疗组在对照组基础上静脉滴注膦甲酸钠氯化钠;治疗3个月后对比两组患者宫颈炎指标评分、宫颈炎指标评分改善率及HPV转阴率。结果治疗后两组患者宫颈炎指标评分均显著降低,其中治疗组宫颈炎指标评分显著低于对照组(t=11.568,P<0.05);治疗总有效率治疗组为96.67%,显著高于对照组的83.33%,两组相比差异有统计学意义(χ2=9.886,P<0.05);治疗3个月后HPV转阴率治疗组为86.67%、对照组为70.00%,两组相比差异有统计学意义(χ2=8.187,P<0.05)。结论膦甲酸钠治疗能够显著提高宫颈炎持续HPV感染患者HPV的转阴率,降低患者炎症程度,值得临床推广。 OBJECTIVE To observe the clinical efficacy of foscarnet sodium and sodium chloride in treatment of the cervicitis infected with human papillomavirus (HPV) and explore new therapies so as to raise the negative rate of HPV infection and reduce the incidence of infections .METHODS A total of 60 cervicitis patients infected with HPV were enrolled in the study and randomly divided into the treatment group and the control group ,with 30 cases in each ,then ,the control group was treated with interferonα-2b bolt ,while the treatment group was given the intravenous administration of foscarnet sodium and sodium chloride on the basis of the treatment in the control group ,and the cervicitis index score ,improvement rate of cervicitis index score ,and negative rate of HPV were compared between the two groups after three months of treatment .RESULTS The cervicitis index score of both groups was significantly decreased after the treatment ,which was significantly lower in the treatment group than in the control group(t= 11 .568 ,P〈 0 .05) .The total effective rate of treatment of the treatment group was 96 .67% ,significantly higher than 83 .33% in the control group ,and there was significant difference between the two groups(χ2 =9 .886 ,P〈0 .05) .After three months of treatment ,the negative rate of HPV was 86 .67% in the treatment group ,70 .00% in the control group , and the difference between the two groups was statistically significant(χ2 = 8 .187 ,P〈 0 .05 ) .CONCLUSIONS Foscarnet sodium can significantly raise the negative rate of HPV in the cervicitis patients infected with persistent HPV and reduce the severity of inflammation ,and it is worthy to be promoted in the hospital .
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2014年第12期2943-2945,共3页 Chinese Journal of Nosocomiology
基金 江苏省预防医学科研基金资助项目(Y2012014)
关键词 膦甲酸钠 宫颈炎 人乳头状瘤病毒 感染 转阴率 Foscarnet sodium Cervicitis Human papillomavirus Infection Negative rate
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参考文献6

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二级参考文献20

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