摘要
目的采用正交试验筛选异烟肼巴布剂的处方。方法以膜残留和涂展性为评价指标进行正交试验,确定最佳处方。结果异烟肼巴布剂处方组成是主药异烟肼∶黏着剂(质量比是1∶3的卡波姆∶NP700)∶保湿剂(甘油)∶交联剂(甘羟铝)=3∶6∶30∶0.1。结论异烟肼巴布剂处方设计较为合理,可进一步开发。
AIM To optimization of the formula of isoniazid cataplasm by orthogonal experiment. METHODS The formula of isoniazid eataplasm was optimized by orthogonal experiment based on two factors ： film residue and spreadability. RESULTS The formula of isoniazid cataplasm was as following：isoniazid was 3 g, 1：3 mass ratio of earbomer： NP700 as adhesive was 6 g, glyeefin as a humeetant was 30 g, and dihydroxyaluminium aminoaeetate as erosslinkers was 0. 1 g. CONCLUSION The formula of isoniazid cataplasm is reasonable and it is worth doing further research.
出处
《中国临床药学杂志》
CAS
2014年第3期170-173,共4页
Chinese Journal of Clinical Pharmacy
基金
广州市医药卫生科技项目(编号20131A011076)
关键词
异烟肼巴布剂
正交试验法
黏着剂
保湿剂
交联剂
处方筛选
isoniazid eataplasm
orthogonal experiment
adhesive
humeetant
erosslinker
optimiza- tion of formula
