5-HTTLPR多态性与环境因素对产后抑郁症的影响

Impact of 5-HTT Gene-Linked Polymorphic Region Polymorphism and Environmental Factors on Postpartum Depression

目的:探讨5-HTT基因连锁多态区(5-HTTLPR)多态性以及环境因素对发生产后抑郁的影响。方法:从武汉大学中南医院随机收集240例产妇(2012年4月至2013年4月),通过爱丁堡产后抑郁量表(EPDS)评分,诊断出39例产后抑郁患者作为观察组,再按照随机抽样的方法从剩下的产妇中抽取39例作为对照组,运用聚合酶链反应技术(PCR)检测两组5-HTTLPR多态性的基因(S和L)和基因型(SS、SL、LL)的分布频率;再对两者之间环境因素进行比较。结果:观察组5-HTTLPR短重复序列/短重复序列(short/short,S/S)基因型和短重复序列(short,S)频率分别为71.8%、83.3%,明显的高于对照组(43.5%、57.5%),两组之间的差异具有统计学意义(P<0.05);环境因素中丈夫的体贴程度、期待胎儿性别、婆媳关系、夫妻关系因素在两者之间的差异具有统计学意义。结论:5-HTTLPR的SS基因型可能是产后抑郁症的易感基因之一,而环境因素是产后抑郁症发病的重要因素。

Objective：To study 5 HTT gene linked polymorphic region （5 HTTLPR） polymorphism and the influence of environmental factors on postpartum depression. Methods： A total of 240 puer- pera from April 2012 to April 201;3 were included in this study, and scored by Edinburgh postna- tal depression scale （EPDS）. Using a polymerase chain reaction-based technique, polymorphism of 5-HTT-linked polymorphic region （5-HTTLPR） in serotonin transporter gene was determined in 39 patients with postpartum depression and 39 control subjects, the allelic and genotypic distri- butions between the two groups were compared. Cases and controls were matched for the envi- ronmental factors. Results： The frequencies of 5-HTT short/short （S/S） genotype and allele S were significantly higher in postpartum depression patients than in the control group （71.8% vs. 43.5%; 83.3% vs. 57.5%; both P〈0.05）. Significant correlations were found between environmental factors and postpartum depression （P^0.05）. Conclusion： The findings support that the presence of allele S may increase the risk for postpartum depression and environmental factors also have impact on postpartum depression.