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血清可溶性髓样细胞触发受体-1和CD64指数测定在新生儿脓毒症早期诊断中的临床意义 被引量：8

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摘要 目的探讨检测血清可溶性髓样细胞触发受体-(sTREM-1)和中性粒细胞表面CD64表达水平对新生儿脓毒症的早期诊断价值。方法将96例住院新生儿按相关疾病诊断分为脓毒症组(33例)、局部感染组(35例)和非感染组(28例),分别应用双抗体夹心酶联免疫吸附法(ELISA)测定血清sTREM-1浓度,应用流式细胞技术测定中性粒细胞表面分子CD64的表达,应用受试者工作特征(ROC)曲线研究sTREM-1、CD64的诊断效能。结果脓毒症组、局部感染组与非感染组血清sTREM-1中位数水平分别为325.25、134.53、8.64ng/L,三组间比较差异有显著性;脓毒症组CD64阳性百分率中位数为62.36%,高于局部感染组和非感染组的21.50%和9.37%,三组间比较差异有显著性。ROC曲线分析显示,血清sTREM-1诊断脓毒症ROC曲线下面积为0.88,在临界值取24.41ng/L时,sTREM-1诊断脓毒症的敏感性为87%,特异度为81%。CD64阳性百分率以42.13%为界时,诊断脓毒症的敏感度为96%,特异度为90%,ROC曲线下面积为0.92。两项指标联合检测,ROC曲线下面积为0.97,敏感性达99%,,特异性为83%。结论外周血sTREM-1、中性粒细胞表面CD64检测可作为新生儿脓毒败血症的早期诊断的可靠指标,两者联合检测更具临床意义。
作者 杨芳 涂芳芳 项文娜 曾绮丹
机构地区 温州医科大学附属第三医院新生儿科
出处 《中国医刊》 CAS 2014年第6期64-66,共3页 Chinese Journal of Medicine
基金 温州市科技计划项目(Y20130262)
关键词 脓毒症 可溶性髓样细胞触发受体-1 CD64 新生儿
分类号 R722.13 [医药卫生—儿科]
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参考文献4

二级参考文献17

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共引文献1072

同被引文献116

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引证文献8

二级引证文献51

中国医刊
2014年 第6期

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