九味镇心颗粒和帕罗西汀治疗精神分裂症伴发焦虑的临床观察

Clinical Effect of Paroxetine and Jiuweizhenxin Granulas in the Treatment of Schizophrenia with Anxiety Symptom

目的:评价九味镇心颗粒与小剂量帕罗西汀治疗精神分裂症伴发焦虑(心脾两虚证)的临床疗效。方法:选择服用非典型抗精神病药物治疗的伴焦虑的精神分裂症患者77例,随机分为九味镇心颗粒组(A组)38例和帕罗西汀组(B组)39例。A组给予九味镇心颗粒,B组给予帕罗西汀,均治疗6周。比较2组疗效及药物不良反应。结果:2组间治疗1、2、4、6周末的HAMA总分差异无统计学意义(P>0.05);2组显效率及有效率差异均无统计学意义(P>0.05);阳性与阴性症状量表中总分及思维紊乱、猜疑/被害、社交退缩等因子评分减分率差异有统计学意义(P<0.05)。结论:九味镇心颗粒在治疗精神分裂症伴发焦虑症状时疗效确切,不良反应发生率低,依从性高,还同时存在协同治疗精神病性症状的疗效。

ObjectiveTo assess the efficacy of Jiuweizhenxin granulas in the treatment of Schizophrenia with anxiety symptom. Methods： Seventy-seven schizophrenic patients with anxiety symptoms （heart and spleen deficiency type） were recruited and were randomly divided into two groups： Jiuweizhenxin granulas, and paroxetin groups （Goups A and B respectively）. All patients had received the atypical antipsychotics. Jiuweizhenxin granulas were given to the patients in the Group A, and paroxetin in the low dose was given to the patients in Group B. The efficacy and adverse effects of the two groups were compared. Results： The Hamilton Anxiety Scale score and efficacy rate are comparable between the two groups at weeks 1, 2, 4, and 6 after treatment （P〉0.05）. Positive and negative symptom scale of thinking disorder, suspicion / victimization, social withdrawal, stress factor score reduction rate showed significant differences between the two groups （ P〈0.05）. Conclusion： Jiuweizhenxin granulas are effective and safe in the treatment of general anxiety disorder.