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兰尼碱受体2与心脏疾病 被引量：2

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摘要 兰尼碱受体（ryanodine receptor,RyR）2为心脏Ca2＋释放通道之一,因它和一种植物碱——兰尼碱具有很高的亲和力与特异性,故而得名.它为同源四聚体细胞内Ca2释放通道大家族成员之一,为RyR亚型之一,主要在心肌表达. 一、RyR2的调节 许多结合在胞浆的N末端的调节物参与RyR2功能的调节.内源性调节,除Ca2＋外还有下列调节物：（1）环磷酸腺苷依赖的蛋白激酶A（PKA）刺激RyR2,过去认为其在S2030位点磷酸化,后认为S2808为主要PKA磷酸化位点[1].（2）钙/钙调蛋白依赖的蛋白激酶Ⅱ（CaMKⅡ）及其异构型钙/钙调蛋白依赖性丝氨酸/苏氨酸激酶（CaMKⅡδ）[2],均对RyR2起刺激作用,使其在S2814位点磷酸化.
作者 胡康新 万懿婷 姚文亮 胡红丁 胡佩
机构地区 南昌市医学科学研究所
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2014年第5期444-446,共3页 Chinese Journal of Cardiology
关键词 兰尼碱受体 心脏疾病 Ca2+释放通道 受体2 RECEPTOR 内源性调节 磷酸化位点 RyR2
分类号 R541 [医药卫生—心血管疾病]
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参考文献27

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二级参考文献24

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共引文献15

同被引文献52

  • 1赵鹏军,孙锟.钙/钙调素依赖的蛋白激酶II对心肌细胞钙循环的影响[J].国外医学（生理病理科学与临床分册）,2004,24(4):357-359. 被引量：3
  • 2李荣,易岂建,钱永如,刘晓燕.卡维地洛对心力衰竭时兰尼碱受体的作用[J].中华儿科杂志,2005,43(8):603-607. 被引量：7
  • 3孙英贤.心律失常的药物治疗进展[J].实用药物与临床,2006,9(2):73-75. 被引量：5
  • 4陈桂荣,陈玉彬.新型钙增敏剂的研究进展[J].实用药物与临床,2006,9(2):123-125. 被引量：2
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中华心血管病杂志
2014年 第5期

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