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FSH和LH联合上调卵巢上皮性癌细胞侵袭能力的机制研究 被引量：1

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摘要 卵巢上皮性癌（卵巢癌）的病死率居妇科恶性肿瘤之首,约90％的卵巢癌被认为起源于正常卵巢表面上皮（ovarian surface epithelium,OSE）或内衬OSE的包涵囊肿.但卵巢癌发生发展的确切机制尚不明确.卵巢癌病情隐匿,易出现侵袭和转移,70％的患者确诊时已处于晚期.目前认为,妇女绝经后或卵巢功能不全者存在高促性腺激素状态,FSH和LH持续刺激可导致细胞过度增殖,最终可引发卵巢癌.
作者 赵婷婷 冯定庆 凌斌
机构地区 安徽医科大学附属省立医院妇产科 安徽医科大学附属省立医院分子医学重点实验室
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2014年第5期381-383,共3页 Chinese Journal of Obstetrics and Gynecology
基金 国家自然科学基金（81072127、81372779、81372777） 安徽省自然科学基金（11040606M176、11040606M178）
关键词 卵巢上皮性癌 癌细胞侵袭能力 FSH LH 妇科恶性肿瘤 卵巢表面上皮 高促性腺激素 卵巢功能不全
分类号 R737.31 [医药卫生—肿瘤]
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参考文献11

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二级参考文献11

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  • 10Ying E Zhang.Non-Smad pathways in TGF-β signaling[J].Cell Research,2009,19(1):128-139. 被引量：70

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中华妇产科杂志
2014年 第5期

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