MAPK信号通路在骨关节炎发病机制中的研究进展

Research progress on MAPK signal pathway in the pathogenesis of osteoarthritis

丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)是真核细胞信号传递的重要途径之一,在调节控制细胞结构和功能活动中发挥关键作用。在真核生物中MAPK信号通路包括p38、ERK、JNK、ERK5等多个亚家族。随着研究的不断深入,发现p38、ERK、JNK信号转导途径的活化与骨关节炎(osteoarthritis,OA)软骨损伤密切相关,诱导软骨细胞产生基质金属蛋白酶,加速关节软骨病理性降解,并参与软骨细胞增殖、凋亡与分化等一系列反应,明确MAPK信号通路在OA中的发生发展机制已成为研究的新热点。

Mitogen-activated protein kinases （MAPKs） signal is one of the important ways in eukaryotic cell,which ad- justs and controls the structure and function of the cell. MAPKs in eukaryotes include p38, ERK, JNK and ERKS, etc. With the deepening research,we found that the activation of p38,ERK,JNK signal pathways were closely related with osteoarthritis （OA） cartilage injury. MAPKs are the key signaling systems involved in the production of matrix metalloproteinases and the regulation of cartilage cell proliferation, apoptosis and differentiation. Expecially the matrix metalloproteinases can accelerate the degradation of articular cartilage. So it has been the new spot in pathogenesis of osteoarthritis study.