氟芬那酸丁酯软膏治疗日光皮炎的临床观察

Butyl flufenamate ointment in the treatment of solar dermatitis： a clinical observation

目的探讨氟芬那酸丁酯软膏治疗日光皮炎的疗效及安全性。方法Et光皮炎患者64例，随机分为观察组和对照组，每组32例。观察组外用氟芬那酸丁酯软膏，对照组外用双氯芬酸钠乳膏，疗程为3周。采用疾病情况评分和瘙痒视觉模拟评分比较氟芬那酸丁酯软膏和双氯芬酸乳膏的疗效。结果观察组临床痊愈4例，显效19例，有效7例，无效2例，总有效率93.8％；对照组临床痊愈2例，显效11例，有效14例，无效5例，总有效率84．4％。观察组总有效率高于对照组，两者差异有统计学意义（P〈0．05）。从瘙痒评分构成比来看，观察组瘙痒评分显著低于对照组，两者差异有统计学意义（P〈0．05）。结论氟芬那酸丁酯治疗日光皮炎疗效优于双氯芬酸，能较好地改善患者瘙痒症状。

Objective To evaluate the efficacy and safety of butyl flufenamate ointment for the treatment of solar dermatitis. Methods Sixty-four patients with solar dermatitis were randomly divided into the observation group （n = 32） and control group （n = 32） to topically apply butyl flufenamate ointment and diclofenac sodium cream, respectively, for 3 weeks. The efficacy was evaluated by lesion scores and a visual analog scale for pruritus. Results At the end of the treatment, 4 patients in the observation group were clinically cured, 19 markedly improved, 17 improved, and 2 showed no improvement; meanwhile, 2 patients in the control group were clinically cured, 11 markedly improved, 14 improved, and 5 showed no improvement. The total response rate was significantly higher （93.8% vs. 84.4%, P 〈 0.05）, while the pruritus score was significantly lower （P 〈 0.05 ） in the observation group than in the control group. Conclusion Butyl flufenamate ointment is superior to dicofenac sodium cream in terms of both efficacy and anti-pruritic effect.