摘要
目的探讨检测肝病患者血清透明质酸(HA)、层黏蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)和Ⅳ型胶原(Ⅳ-C)的临床意义。方法采用放射免疫法测定肝脏疾病患者(A组,60例)和健康人群(B组,100例)血清HA、LN、PC-Ⅲ和Ⅳ-C水平,分析其与肝脏疾病的关系。A组包括肝硬化(HC,8例)、肝癌(LC,4例)、慢性病毒性肝炎(CPH,30例)和急性病毒性肝炎(AIH,18例)患者。结果 A组HA、LN、PC-Ⅲ和Ⅳ-C水平由高到低分别为HC、LC、CPH和AIH;HC组的4项指标分别为(481.1±42.2)ng/ml、(252.3±30.6)ng/ml、(263.1±40.4)ng/ml和(239.1±39.3)ng/ml,均明显高于B组的(51.1±12.5)ng/ml、(59.43±20.4)ng/ml、(63.4±20.4)ng/ml和(54.4±14.4)ng/ml(P<0.05),亦明显高于LC、CPH和AIH组(P<0.05)。结论血清HA、LN、PC-Ⅲ和Ⅳ-C水平能反映肝纤维化的程度,可用于肝硬化的早期诊断和肝脏疾病病情的动态评估。
Objective To study the detection of serum hyaluronic acid（HA）, laminin（LN）, precollagen Ⅲ （PC-Ⅲ） and collagen Ⅳ （Ⅳ-C） and its clinical significance in the patients with hepatic diseases. Methods Senum levels of HA, LN, PC-Ⅲ and Ⅳ-C were detected by radioimmunity method in 60 patients （group A） with hepatocirrhosis （HC, 18 cases）, liver cancer （LC, 4 cases）, chronic persisting hepatitis（CPH, 30 cases） and acute icterus hepatitis （AIH, 18 cases）. The results were compared to those of 100 healthy people（group B）. The differences of senum levels of HA, LN, PC-Ⅲ and Ⅳ-C among hepatic diseases were analyzed. Results Senum levels of HA, LN, PC-Ⅲ and Ⅳ-C were in an order of HC〉LC〉CPH〉AIH. Senum levels of HA, LN, PC-Ⅲ and Ⅳ-C in group HC were（481.1±42. 2） ng/ml, （252. 3±30. 6） ng/ml, （263. 1 ±40. 4） ng/ml and （239. 1 ±9. 3） ng/ml, respectively,which were significantly higher than （51.1± 12.5） ng/ml, （59.43±20.4）. ng/ml, （63.4 ±20. 4） ng/ml and （54. 4±14. 4） ng/ml in group B（P〈0. 05） ,and those in groups of LC,CPH and AIH（P〈0. 05）. Conclusion The combined detection of serum HA,LN,PC-Ⅲ and Ⅳ-C can show the degree of cirrhosis and is valuable for early diagnosis of hepatocirrhosis and efficacy evaluation of treatment in the patients with liver diseases.
出处
《江苏医药》
CAS
北大核心
2014年第10期1176-1178,共3页
Jiangsu Medical Journal
