断骨丹剂型优化对兔桡骨骨折愈合弯曲载荷的影响

BIOMECHANICAL INVESTIGATION OF OPTIMIZED FORM OF DUANGUDAN ON FRACTURE HEALING

目的：观察经剂型优化后断骨丹贴剂有无促进兔桡骨骨折的愈合作用。方法：家兔７２只，其中８只未造模作正常值测定，６４只手术造成右桡骨中段骨折，并分为空白组、断骨丹传统剂型组、普通方法提取浸膏贴膏组、剂型优化提取浸膏贴膏组，于２周、４周分别处死，取出骨折的桡骨进行弯曲载荷测定进行对比观察。结果：２周中的４组按弯曲载荷从大到小排列为剂型优化后提取浸膏贴膏组、普通方法提取浸膏贴膏组、断骨丹传统剂型组、空白组。４周中的４组弯曲载荷与２周组排列相同，而剂型优化后提取浸膏贴膏组在２周和４周均与空白组有显著差异。结论：断骨丹经剂型优化提取浸膏制成的贴膏对兔桡骨骨折愈合有促进作用，并优于传统剂型断骨丹。

Objective:To investigate the curative effects of optimized form of Duangudan on fracture healing. Method: 64 cases of rapine distal radial fracture models were randomized into 4 groups, blank control group (normal fracture healing without treatment) group of conventional form of Duangudan, group of emplastrum form prepared from conventional extractum, group of emplastrum form prepared from optimized extractum. Meanwhile, eight cases with intact radii were sacrificed from normal control. They were sacrificed at 2nd and 4th week in batches. All involved radii were harvested for biomechanical observation (three-point bending test). Results: At the end of 2nd week, in order of curative effect, the groups were ranked as follows, group of emplastrum form prepared from optimized extractum, goup of previous form of Duangudan, an blank control group. At the end of 4th week, the rank remained all the same as that at the end of 2nd week. There was significant difference in biomechanical test between the emplastrum form prepared from optimized extractum and blank control at both ends of 2nd and 4th week. Conclusion:The emplastrum form prepared from optimized extractum was superior to the conventional form in enhancing fracture healing.