内皮细胞-血小板血栓定量分析系统

A Computer Image Processing System to Analyze Endothelial Cell Platelet Thrombus Quantitatively

我们开发了一套计算机图像处理系统 ,用于定量分析体外锥 -板血流模拟装置实验中内皮细胞 -血小板的相互作用。测量的参数包括反映在流态下内皮细胞形态变化的细胞面积、周长、长轴、短轴、形态指数和倾斜角 ,和反映流动状态下血小板 -内皮细胞相互作用的相关参数血小板粘附率、表面粘附密度、血小板扩散系数和表面作用常数等。

A Computer Image Processing System for cone plate rolling model which forms endothelial cell platelet thrombus in vitro is presented in this paper. Some parameters such as endothelial cell shape parameters(area, perimeter, long axial length, short axial length, angle of orientation, and shape index), platelet adhesion coverage, platelet adhesion density, diffusivity and surface reactivity constant are measured during the reaction of endothelial cells and platelet under the fluid shear stress condition. The invitro thrombus model and the corresponding quantitative analysis system is useful in the studies on endothelial cells platelets interaction and mechanism of thrombosis and atherosclerosis.