非糖尿病腹膜透析患者糖化血红蛋白水平与冠状动脉狭窄的相关性

Correlation between glycosylated hemoglobin and magnitude of coronary artery stenosis in non-diabetic patients receiving abdominal dialysis

目的:探讨非糖尿病腹膜透析惠者糖化血红蛋白(HbAlc)水平与冠状动脉狭窄的相关性。方法:分析2011年1月至2013年7月在百色市人民医院进行持续不卧床腹膜透析治疗的38例非糖尿病成年慢性肾脏病患者的临床资料,按照有无冠状动脉狭窄将患者分为对照组(20例)和冠状动脉狭窄组(18例)。比较两组危险因素及检验指标的差异,分析冠状动脉狭窄的影响因素。结果:冠状动脉狭窄组的收缩压、FBG、2 hPBG、LDL-C、TC和HbAlc均高于对照组(P<0.05)。冠状动脉狭窄与年龄、收缩压、FBG、2hPBG、LDL-C、TC、HbAlc呈正相关(P<0.05),而HbAlc对冠状动脉狭窄的影响最大。结论:在非糖尿病腹膜透析患者中,HbMc水平与冠状动脉狭窄呈正相关,HbAlc可能是冠状动脉狭窄的预测因子。

Objective：To investigate the correlation between glycosylated hemoglobin （HbAlc） and the magnitude of coronary artery stenosis in non-diabetes mellitus patients receiving abdominal dialysis. Methods： We analyzed the clinical profiles of 38 non-diabetic patients with chronic kidney disease who were receiving ambulatory abdominal dialysis in Baise People＇ s Hospital between January 2011 and July 2013. Patients were further stratified to control group （n =20） and coronary artery stenosis group （n = 18） for comparison on the risk fators and the clinical indices. Results ： The coronary artery stenosis group yielded higher levels of systolic blood pressure, FBG, 2hPBG, LDL-C, TC and HbAlc than control group （ all P 〈 0.05）. The magnitude of coronary artery stenosis was positively correlated with the age, systolic blood pressure, FBG, 2hPBG, LDL-C, TC and HbAlc （all P 〈 0. 05, in particular the level of HbAlc. Conclusion： In non-diabetic patients receiving abdominal dialysis, the level of HbAlc is positively correlated with the magnitude of coronary artery stenosis, suggesting that it is a predictor of coronary artery stenosis.