受体介导的蛋白多肽靶向药物载体的应用研究

The Research of Receptor mediated Drug Carrier

综述了近年来利用配体 -受体的特异性结合 ,以蛋白质及多肽作为药物载体 ,将药物定向转运到特定靶组织方面研究的进展。介绍了常用的受体及相应的药物载体 ,载体定向转运药物的机理及常用的三种药物与载体的连接方式 ,即酸敏感性共价键 ,疏水键及离子键 。

One way to increase the concentration of drug in diseased tissue is to attach drug to a suitable carrier such as protein or peptides, which can improve the pharmacokinetic properties of drug and decrease it's side-effect on normal tissue. The developments of receptor-mediated transporting of drug associated with protein or peptides are reviewed in this paper. The most frequently used receptors and drug carriers and the bonds between the drug and the carrier are introduced. The mechanism of transporting and the factors that affect the efficiency of the drug carrier are discussed as well.