摘要
目的探讨胃癌组织中peroxiredoxin 1(Prdx1)蛋白的表达水平及其与胃癌临床病理特征和预后的关系。方法采用组织芯片和免疫组化法检测120例胃癌及对应癌旁组织中Prdx1蛋白的表达情况,分析其与临床病理特征及总生存期(OS)的关系。结果胃癌和癌旁组织中Prdx1的阳性表达率分别为58.3%(70/120)和25.0%(30/120),差异有统计学意义(P=0.001)。Prdx1蛋白表达与淋巴结转移(P=0.015)和TNM分期(P=0.006)有关,与年龄、性别、部位、肿瘤大小、组织分化和浸润深度无关。Prdx1阳性表达者的中位OS为56.0个月,短于阴性者的81.7个月(P=0.004)。Prdx1是影响Ⅰ、Ⅱ期胃癌预后的独立因素(P=0.030)。结论 Prdx1在胃癌组织中表达上调,与胃癌的发生、发展有关,可作为判断早期胃癌预后的指标。
Objective To explore the expression of peroxiredoxin 1（ Prdx1） protein in gastric cancer and determine the rela-tionship of its expression with clinical features and prognosis. Methods Tissue microarray blocks containing gastric cancer tissues and adjacent non-cancerous tissues from 120 patients were constructed. Expression of Prdx1 in gastric cancer tissues and adjacent non-cancer-ous tissues were analyzed using immunohistochemical study. The relationship between the expression of Prdx1 and clinicopathological characteristics were analyzed as well as the overall survival（OS）. Results The positive rates of Prdx1 in tumor and adjacent non-cancer-ous tissues were 58.3%（70/120） and 25.0%（30/120） with significant difference（P = 0.001）. Over-expression of Prdx1 was significantly associated with lymph node metastasis（P=0.015）and TNM stage（P=0.006）, but not with age, gender, tumor position, tumor size, differentiation and invasive depth. The median OS of patients with Prdx1 positive expression was 56.0 months, significantly shorter than 81.7months of Prdx1 negative expression （ P= 0.004）. Multivariate analysis revealed that Prdx1 was an independent prognostic factor in patients of stageⅠ/Ⅱ. Conclusion Prdx1 expression significantly increases in gastric cancer, suggesting the potential role of Prdx1 in cancer development and progression. Prdx1 expression can be used to predict patients. outcome of gastric cancer.
出处
《临床肿瘤学杂志》
CAS
2014年第5期417-420,共4页
Chinese Clinical Oncology
基金
上海市浦江人才计划资助项目(13PJD003)
