人工肝脏辅助装置吸附剂——交联琼脂糖包膜活性炭微囊制备中的质量控制

Preparation and Quality Control of Cross linked Agarose Coated Activated Charcoal (CAAC II) Used as Adsorbents for Hemoperfusion in Artificial Liver Support

报道了交联琼脂糖包膜活性炭 (CAAC- II)微囊制备过程中的质量控制、环氧氯丙烷的清除。分析测试表明 ,试样溶液中微量元素铅、镉、砷、铬、铁及重金属总含量 ,以及 p H值、NH4+、SO42 -、紫外吸收度等均符合中国药典 (1985版 )及有关部颁标准规定。

The preparation and the quality control of cross-linked agarose coated activated (CAAC-II) were described. The crosslinking reagent epichlorohydrin was removed. Investigations indicate that the trace elements such as Pb, Cd, As, Cr, Fe and heavy metals, the pH, NH4+, SO42-, and ultraviolet absorbance in sample have met the requirements in Chinese Pharmacopeia and some other relevant standard promulgated by the Ministry of Health. No epichlorohydrin was detected in CAAC-II.