IL-16和IL-17在变应性及非变应性鼻炎中的表达水平及意义

Analysis of the level and significance of IL-16 and IL-17 in nasal secretion and in serum of patients with allergic rhinitis and non-allergic rhinitis

目的:检测变应性鼻炎(AR)、非变应性鼻炎(NAR)患者和健康对照者在外周血及鼻分泌物中IL-16和IL-17的表达水平,初步探讨IL-16和IL-17可能参与AR发病的免疫学机制。方法:选取AR患者(AR组)与NAR患者(NAR组)各45例,健康对照者45例(对照组),所有入组患者均进行过敏原皮肤点刺试验和血清特异性IgE检测。对入组的所有患者进行鼻部症状的视觉模拟量表评分(VAS)。采集患者外周血及鼻腔分泌物,检测其中IL-16和IL-17的表达水平。结果:AR及NAR组患者VAS评分差异无统计学意义(P>0.05);在外周血中,AR组中IL-16和IL-17表达水平高于NAR组(P<0.05);NAR组中IL-16和IL-17表达水平高于对照组(P<0.05)。鼻分泌物中,AR组和NAR组中IL-16和IL-17表达均高于对照组(P<0.05)。结论:IL-16和IL-17可能参与AR的病理过程,具体机制有待进一步探讨。

Objective：To test the immunoglobulin free light chain（FLC） from nasal secretion and serum of patients with allergic rhinitis（AR）and non-allergic rhinitis（NAR） for the purpose of exploring the possible immunological mechanism. Method：Ninety consecutive patients were selected between January 2009 and January 2012,involving 45 patients with AR and 45 patients with NAR diagnosed by symptoms, signs, skin prick tests（SPT） and specific IgE（sIgE）. Forty-five volunteers were chosen as healthy control（HC）. According to the visual analogue scale （VAS） scores, the nasal symptoms of AR and NAR,including sneeze. Nasal discharge. Nasal obstruction and nasal itching were compared. ELISA was used to detect the total IgE, IL-16, IL-17 in nasalseeretion and serum. The data was analyzed by SPSS 17.0 software. Result： There was no statistical difference between AR and NAR group in nasal symptoms（P〉0.05） ;In serum,IL-16 and IL-17 increased in AR group comparared to NAR group（ P〈0.05） ; IL-16 and IL-17 increased in NAR group comparared to HC group（all P〈0.05） ; In nasal secretion,IL- 16 and IL-17 increased in NAR and AR group comparared to HC group（all P〈0.05）. Conclusion： IL-16, IL-17 takes part in the path of physiological process of AR and NAR with the immunological mechanism.