胃肠道炎性纤维性息肉的临床与病理分析

Clinical and pathological analysis of inflammatory fibroid polyps of gastrointestinal tract

目的 探讨胃肠道炎性纤维性息肉 (IFP)的诊断、病理学特点及治疗原则。 方法 对1984年～ 1999年经治的 12例IFP的临床和病理资料进行分析总结。 结果 12例均表现为胃肠道粘膜下息肉样肿块 ,以纤维血管增生 ,呈特征性排列和嗜酸性粒细胞浸润为其组织学特征 ,免疫组化结果显示病变组织表达纤维和肌纤维母细胞标记。本组均经手术切除或内镜下摘除。 11例获随访 ,其中 2例出现复发 ,均予再次手术切除 ;其余病例均恢复满意。 结论 IFP是胃肠道少见的良性病变 ,可能是对感染、异物或损伤等的过度反应 ;病理上有特征性组织学改变 ,应注意与胃肠道肿瘤或其它息肉样病变的鉴别 ;手术切除或内镜下摘除为其主要治疗方法。

Objective To investigate the pathological characteristics, diagnosis and treatment of inflammatory fibroid polyps (IFP) of the gastrointestinal tract. Methods Clinicopathological data of 12 cases of IFP collected from 1984 to 1999 were analyzed retrospectively. Results All the 12 cases were found submucosal polyps of the gastrointestinal tract, composed of fibroblasts and blood vessels infiltrated by numerous eosinophil leukocytes. Immunohistochemical staining demonstrated that the lesions showed fibroblastic and myofibrolastic sign. All the cases underwent dissection endoscopecally. Eleven cases were followed up, and 2 of them were reoperated on because of recurrence. The remaining recovered. Conclusions IFP is a rare benign disease of the gastrointestinal tract, representing an exaggerated response to infection or other injury. It is characterized by histological changes, like gastrointestinal tumors or other polypoid lesions. Local resection or endoscopic removal is the major treatment.