CRP、ADA、LP联合检测在鉴别胸腔积液性质中的临床意义

Value of leptin,C-reactive protein and ADA joint-detection in the diagnosis of pleural effusions

目的探讨C反应蛋白(C-reactive protein,CRP)、腺苷脱氨酶(adenosine deaminase,ADA)和瘦素(leptin,LP)联合检测在鉴别胸腔积液性质中的临床意义。方法选取结核性及恶性胸腔积液住院患者各30例,同时选取30例健康体检者为对照组,采用ELISA法检测患者血清、胸腔积液中CRP、ADA及LP含量。结果结核患者血清中CRP及ADA水平明显高于恶性组及对照组(P<0.05),结核患者胸腔积液中CRP及ADA水平明显高于恶性组(P<0.05);恶性组患者血清中CRP水平高于对照组患者(P<0.05),恶性组患者和对照组患者血清中ADA水平差别无统计学意义(P>0.05);恶性组患者血清中LP水平显著高于结核组及对照组(P<0.05),恶性组患者胸腔积液中LP水平显著高于结核组(P<0.05),结核组患者与对照组患者血清中LP水平差别无统计学意义(P>0.05)。结论血清、胸腔积液中CRP、ADA和LP水平对结核性、恶性胸腔积液的鉴别诊断具有重要价值。

Objective To investigate the value of leptin （LP）, C-reactive protein （CRP） and adenosine deaminase （ADA） joint-detection in the diagnosis of pleural effusions. Methods CRP, ADA and LP levels were detected with ELISA in pleural effusion and serum in 30 patients with purulent pleuritis, 30 patients with tuberculous pleurtits. CRP, ADA and LP levels were detected with ELISA in serum in 30 healthy persons of control group. The CRP, ADA and LP levels of three groups were compared. Results The CRP and ADA levels in serum of the TB group were higher than that of malignant group and control groupl obviously （P 〈 0. 05 ）. The CRP and ADA levels in pleural effusion of the TB group were higher than that of malignant group obviously （P 〈 0. 05 ）. The CRP levels in serum of the malignant group were higher than that of control groupl obviously （ P 〈 0. 05 ）. The LP levels in serum of malignant group were higher than that of TB group and control groupl obviously （ P 〈 0. 05 ）. The LP levels in pleural effusion of malignant group were higher than that of TB group obviously （ P 〈 0.05 ）. Conclusion United detection of CRP, ADA and LP in serum and pleural effusion has important significance for the differential diagnosis of the pleural effusion.