4%氯化钠溶液雾化吸入在轻中度毛细支气管炎患儿中的应用价值

Application value of 4% sodium chloride solution atomization inhalation in mild and moderate bronchiolitis of children

目的探讨雾化吸入4%高渗盐水(4%NaCl)治疗轻、中度毛细支气管炎患儿的临床疗效及应用价值。方法将178例轻、中度毛细支气管炎患儿采用随机双盲对照方式分成治疗组和对照组,在常规治疗基础上治疗组89例雾化吸入4%NaCl溶液2.0 mL另加硫酸沙丁酰胺2.5 mg;对照组89例雾化吸入0.9%NaCl溶液2.0 mL另加硫酸沙丁酰胺2.5 mg,8 h/次直至症状完全消失。观察患儿治疗前后身体指标、主要症状变化情况及住院时间的差异。结果治疗组喘息缓解时间、体温恢复时间、咳嗽消失时间、肺部哮鸣音及湿罗音恢复时间、住院天数与对照组比较均缩短,治疗组总有效率91.01%,明显高于对照组总有效率73.03%,差异有统计学意义(P<0.05)。结论雾化吸入4%NaCl溶液治疗轻中度支气管炎患儿能快速缓解症状,降低并发症,缩短病程,临床疗效显著。

Objective To investigate the curative effect and clinical application value of inhalation of 4% hypertonic saline （4% NaCl） for treatment of mild and moderate capillary bronchitis in children. Methods One hundred seventy-eight patients with mild and moderate bronchiolitis were divided into treatment group and control group by double-blind contrastive methods. On the basis of conventional therapy, the 89 cases of the treatment group were given 2.0 mL of 4% NaCl inhalation solution plus 2.5 mg of sulfate sardine amide; 89 cases in the control group inhaled 2.0 mL of 0. 9% NaCl solution plus 2.5 mg of sulfate sardine amide, with 8 h per time until the symptoms completely disappeared. The changes of main indexes related to body and the changes of symptoms and hospitalization time difference were observed before and after treatment. Results Asthmatic response time, recovery time of body temperature, cough disappearing time, recovery time of pulmonary wheezes and crackles, and hospitalization time in treatment group were shortened compared with those of the control group. And the total effective rate of treatment group was 91.01%, significantly higher than that in the control group, whose total efficiency was 73.03 %, the difference was statistically significant （P 〈 0. 05 ）.Conclusion By given 4% NaCl inhalation solution in patients with mild and moderate bronchitis, the symptoms can be quickly relieved, complications can be reduced, and the course of disease Can be shortened, therefore, it has clinical curative effect.