脱钙冻干骨混合自体骨髓治疗下颌骨囊肿摘除术后骨缺损

Treatment of intraosseous cystic lesions of the mandible by conservative enucleation and cavity filling with allogenic freezedried bone mixed with autologous bone marrow

目的探讨脱钙冻干骨混合自体骨髓治疗下颌骨囊肿摘除术后骨缺损的疗效。方法42例下颌骨囊肿摘除术后采取脱钙冻干骨混合自体骨髓填充缺损，观察手术临床效果，并行术前术后放射线检查。结果1例术后出血，2例创口延期愈合，随访13～48个月2例牙源性角化囊性瘤复发，其余术后愈合良好。结论脱钙冻于骨混合自体骨髓可用来治疗下颌骨囊肿摘除术后骨缺损。

Objective To evaluate the outcome of defect filling with allogenic freeze-dried bone mixed with bone marrow following conservative enucleation of large intraosseous cystic lesions of the mandible. Methods Forty-two patients with large intraosseons cystic lesions of the mandible were treated by defect filling with allogenic freeze-dried bone combined with bone marrow following conservative cyst enucleation. All patients were evaluated postoperatively by repeated clinical examination done by the operating surgeon. Radiographic examination was performed using panoramic radiographs taken before operation,immediately after operation,6 months and 12 months after operation. Results Postoperative hemorrhage occurred in one patient. Wound dehiscence occurred in two patients, and the woundhealing was delayed. All patients showed satisfactory healing. The patients were followed-up for 13-48 months using panoramic radiographic examination. Recurrence was seen in 2 patients with KCOTs. Clinical and panoramic radiographic examination showed no residual or recurrent cyst in the remaining patients. Conclusions We demonstrate successful clinical application of allogenic freeze-dried bone mixed with autologous bone marrow as an alternative filling material for intraosseous cystic lesions of the mandible after conservative enucleation.