速冻玻璃化储存异体皮的临床应用

The clinicalapplication of allograft skin preserved by vitrification

目的：分析和总结自 1987 年以来速冻玻璃化储皮临床应用情况。方法：搜集我科 1987 年至 1999 年使用速冻玻璃化储存的异体皮救治烧伤患者临床资料以及我科皮库储存异体皮国内使用情况，总结和分析速冻玻璃化储存异体皮的临床应用效果和异体皮的使用情况。结果：使用速冻玻璃化异体皮的烧伤患者平均烧伤面积为 55.4%，其中平均Ⅲ度面积为 30.9%，应用异体皮面积为 3. 466-10. 208cm2。采用速冻玻璃化保存的皮肤复温后其活力可达到新鲜皮肤的 70% 左右，该法保存的皮肤质地柔软，转红快，成活率高，存活期长，最长可在患者创面上成活 2 个月左右。术后异体皮成活率为 95%。从1987 年至 1999 年底我科皮库供全国各地 18 个省和 3 个自治区的 48 个市，8 个县的 108 家各级医院冷冻异体皮使用，包括我科自用，共使用皮肤面积达3 604 260 cm2。结论：采用速冻玻璃化储存的异体皮覆盖创面，仍是目前最有效、最方便、经济实惠的方法，使用异体皮进行烧伤的救治已经成为国内大多数医院普遍使用的一项救治措施。

Objective:The purposeof this article is to analysisand sum up the clinicalapplication of allograft skin preserved by vitrification Methods: The clinical data of burn patients from 1987 to 1999 which were treated by allograft skin preserved by vitrification in our department, were collected Then the clinical effects of allograft skin were summed up Also the domestic utilizationof allograft skin stored by our skin bank is analysised Results: According to the burn patients treated by allograft skin preserved by vitrification, the average total burn area is 554%,the averageⅢ°area is 309% ,the average area of applied allograft skin is 3466cm2to 10208cm2 The viability of thawed skin preserved by vitrification can reach to 70% of fresh skin The skin stored by this method can survive 2 months on the wound of burn patients The survival of skin after grafting can reach to 95%。Form 1987 to 1999 the cryopreserved skin of our skin bank have covered108 different grades hospitals distributing 48 towns and 8 counties of 18 provinces and 3 municipalities The total area of cryopreserved skin including those used by ourselvesis 3604260cm2Conclusion:The method of the coverage of burn wound with allograft skin preserved by vitrification is still the most effective, convenientand economy one among the treatments of burn patients Moreover this method is an universal treatment of burn in domestic hospitals