造血干细胞移植后患者性功能状况调研

A survey of sexual function and marital status of patients following hematopoietic stem cell transplantation

目的：探讨造血干细胞移植（HSCT）后患者性功能状况及对婚姻和生育能力的影响。方法：通过对 HSCT 后患者发放随访调查表，对生育、性功能改变、婚姻及女性月经情况等进行综合分析研究。结果：在资料完整的 50 例患者中，性欲及性功能正常者分别为 66.6％ 和 80％；性功能改变与 TBI 剂量关系不密切；移植前后 FSH、LH、PRL、睾酮及雌二醇测定结果对比表明差异不明显（P＞0.05）；18 例女性患者，14 例闭经（77.8％），4 例月经恢复（22.2％）；32 例已婚者中，无 1 例怀孕。结论：HSCT 后生育能力及女性月经均有明显影响，对性功能影响不明显，对性激素水平的影响有待继续观察。

Objective:To study effects of hematopoietic stem cell transplantation (HSCT) on sexual function, in 50 patients who received HSCT. Methods:The follow up forms were sent to patients by investigator. The changes of sexuality, sexual function, procreation, female menstruation and serum level of sexual hormones were analyzed.Results:The fourteen out of 18 female patients had amenorrhea (77.8%) after HSCT. None of 32 married patients was pregnant. The sexuality and sexual function of the patients recovered to normal in 66.6% and 80.0%, respectively. There were no significant difference in serum level of sexual hormones before and after transplantation. Conclusion:The effects of HSCT on procreation and female menstruation are obvious, but sexual function are not. It is need more patients and longer follow up to evaluate the serum level of sexual hormones.