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MIIP通过HDAC6参与肿瘤侵袭转移的研究进展 被引量：4

Research progress of migration and invasion inhibitory protein involved in tumor invasion and metastasis through HDAC6
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摘要 迁移侵袭抑制蛋白(migration and invasion inhibitory protein,MIIP),是近年来研究发现的潜在肿瘤转移抑制基因,定位于1p36,该区域在多种肿瘤中缺失。MIIP的定位提示其可能在肿瘤侵袭、转移中发挥作用,并且已有研究报道MIIP可抑制胶质瘤及乳腺癌的侵袭转移。本文就MIIP通过HDAC6在肿瘤侵袭转移中的作用及其分子机制作一综述。 Migration and invasion inhibitory protein（ MIIP）gene was recently discovered candidate tumor suppress gene which located at chromosome 1p36. 1p36 deletion was found in many types of tumor. We hypothesized that MIIP is a potential negative regulator of tumors. It was reported that MIIP could inhibit glioma and breast cancer-cell mi-gration and invasion. This review summarizes the current progress in the research field of MIIP influencing tumor inva-sion and metastasis through HDAC6.
作者 王一维 辛彦
机构地区 中国医科大附属第一医院肿瘤研究所胃肠肿瘤病理研究室普通外科研究所肿瘤病理研究室
出处 《现代肿瘤医学》 CAS 2014年第6期1448-1450,共3页 Journal of Modern Oncology
基金 国家自然科学基金(编号:81071650 30973503) 辽宁省科技厅科学技术计划项目(编号:2013225303-103 2011404013-3) 辽宁省高等学校攀登学者计划(编号:2009-2012)
关键词 迁移侵袭抑制蛋白 肿瘤 侵袭 转移 组蛋白去乙酰化酶6 migration and invasion inhibitory protein（ MIIP ） tumor invasion metastasis histone deacetylase 6 （ HDAC6 ）
分类号 R730.23 [医药卫生—肿瘤]
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参考文献41

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同被引文献32

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现代肿瘤医学
2014年 第6期

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