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胶质瘤与PDCD4的研究进展 被引量：2

The lastest development of PDCD4 in glioblastoma
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摘要 PDCD4(Programmed cell death 4)是近年来发现的与细胞凋亡相关的新的肿瘤抑制基因,研究发现PDCD4在多种肿瘤中存在缺失或下调,并影响肿瘤细胞的生物学行为。PDCD4是否是肿瘤细胞凋亡的关键因子?能否成为胶质瘤治疗的新的突破点?本文将围绕PDCD4最新研究进展,及其与胶质瘤的凋亡的相关性进行综述。 The novel tumor suppressor gene PDCD4（ programmed cell death 4）was found related to cell apoptosis in recent years,the research found that PDCD4 has down-regulation or even deletion in a wide variety of tumor,and af-fect the cell biological characteristics of tumor cells. Whether the PDCD4 could became to the key factor of the tumor cell apoptosis or not？Could it become the new breakthrough of glioma treatment？This article reviewed around the re-cent development of research with PDCD4 and its correlation with apoptosis of glioma.
作者 卢鑫 左频 郭婉莹 赵喆 罗林
机构地区 昆明医科大学第三附属医院 云南省肿瘤医院
出处 《现代肿瘤医学》 CAS 2014年第6期1465-1467,共3页 Journal of Modern Oncology
基金 云南省教育厅科学研究基金重点项目(编号:2012Z079)
关键词 PDCD4 胶质瘤 氧化胁迫 抑癌基因 PDCD4 glioma oxidative stress cancer suppressor gene
分类号 R730 [医药卫生—肿瘤]
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参考文献23

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同被引文献26

  • 1Yiming Li,Weiqing Li,Yongji Yang,Yicheng Lu,Cheng He,Guohan Hu,Huimin Liu,Juxiang Chen,Jin He,Hongyu Yu.??MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme(J)Brain Research . 2009
  • 2Yang Chen,Wei Liu,Tengfei Chao,Yu Zhang,Xingqi Yan,Yanhua Gong,Boqin Qiang,Jiangang Yuan,Maosheng Sun,Xiaozhong Peng.??MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G(J)Cancer Letters . 2008 (2)
  • 3Jose G. Teodoro,Sara K. Evans,Michael R. Green.??Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome(J)Journal of Molecular Medicine . 2007 (11)
  • 4Chan JA,Krichevsky AM,Kosik KS,et al.MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Research . 2005
  • 5Shi Lei,Cheng Zhihao,Zhang Junxia,Li Rui,You Yongping,Fu Zhen.(The mechanism of apoptosis in human U87 glioma cells induced by miR-21 antisense oligonucleotide)Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics . 2008
  • 6P. Mathijs Voorhoeve,Carlos le Sage,Mariette Schrier,Ad J.M. Gillis,Hans Stoop,Remco Nagel,Ying-Poi Liu,Josyanne van Duijse,Jarno Drost,Alexander Griekspoor,Eitan Zlotorynski,Norikazu Yabuta,Gabriella De Vita,Hiroshi Nojima,Leendert H.J. Looijenga,Reuven Agami.??A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors(J)Cell . 2006 (6)
  • 7Xi Yaguang,Shalgi Reut,Fodstad Oystein,Pilpel Yitzhak,Ju Jingfang.Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clinical cancer research : an official journal of the American Association for Cancer Research . 2006
  • 8Xuan Zhou,Yu Ren,Lynette Moore,Mei Mei,Yongping You,Peng Xu,Baoli Wang,Guangxiu Wang,Zhifan Jia,Peiyu Pu,Wei Zhang,Chunsheng Kang.Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Laboratory Investigation . 2010
  • 9Frankel, Lisa B.,Christoffersen, Nanna R.,Jacobsen, Anders,Lindow, Morten,Krogh, Anders,Lund, Anders H.Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. Journal of Biological Chemistry . 2008
  • 10Papagiannakopoulos Thales,Shapiro Alice,Kosik Kenneth S.MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Research . 2008

引证文献2

二级引证文献15

现代肿瘤医学
2014年 第6期

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