重庆市敬老院中老年人血清维生素A与血脂水平的相关分析

Correlation between serum vitamin A and blood lipid among middle-to-old-aged population in gerocomium of Chongqing

目的：通过重庆市敬老院中老年人群中血清维生素A（vitamin A，VA）浓度及血脂水平的调查，分析VA与甘油三酯（triglycefide，TG）、总胆固醇（total cholesterol，TC）、低密度脂蛋白（low density lipoprotein，LDL）、高密度脂蛋白（high density lipoprotein，HDL）之间的相关关系，探讨VA影响血脂的可能机制。方法：采用分层整群随机抽样的方法，在重庆市12家敬老院抽取合格志愿受试者进行研究。采用反相高效液相色谱法（high pertbrmance liquid chromatography，HPLC）检测血清中的VA浓度，西门子2400生化检测仪检测血清血脂各项指标。结果：纳入样本共480例。中老年人群血清VA显著影响LDL（β=-0．068，P=0．017，）与TG（β=-0．338，P=0．000）水平。70～80岁年龄组血清VA对LDL的影响最大（β=-0．136，P=-0．005），并且血清VA是高LDL的保护因素（OR=0．286，95％C1=0．110～0．747）。结论：重庆市敬老院人群的血清VA显著影响血液中LDL水平，而并未影响HDL和TC水平。70—80岁老年人血清中VA浓度对LDL水平的影响最大。VA显著影响TG，具体机制有待进一步研究．

Objective：To study the correlation between serum vitamin A（VA） and blood lipid triglyceride（TG）,total cholesterol（TC）, low density lipoprotein（LDL）,high density lipoprotein（HDL） by researching the levels of VA and lipid among people aged 50 years old or more in gerocomium of Chongqing and to explore the possibly mechanism between VA and lipid. Methods： A total of 480 people meeting the inclusion criteria were randomly recruited from 12 gerocomiums of Chongqing. Serum VA and blood lipid were measured by high performance liquid chromatography and Siemens 2400 biochemical detector, respectively and their correlation was analyzed. Results：Serum VA was negatively correlated with LDL significantly （β=-0.068,P=0.017） and was not correlated with TC and HDL. There was significant correlation between serum VA and TG（β=-0.338,P=0.000）. The most significant correlation between serum VA and LDL was seen in 70-80 years old（β=-0.136,P=0.005）,and VA was a protective factor for the prevalence of high LDL （OR=0.286,95%CI=0.110-0.747）. Conclusions ：VA is significantly correlated with LDL but not with HDL and TC in gerocomium of Chongqing. The most significant correlation between serum VA and LDL is seen in 70-80 years old group. There is significant correlation between VA and TG,the mechanism of which should be studied further.