偏头痛患者血浆一氧化氮和内皮素含量的相关性研究

CORRELATIVE STUDY OF PLASMA ENDOTHELIN AND NITRIC OXIDE LEVELS IN PATIENTS WITH MIGRAINE

目的 :观察偏头痛患者急性发作期及缓解期血浆一氧化氮 (NO)和内皮素 (ET)的含量变化及探讨两者在偏头痛发病机制中的作用。方法 :应用高效液相色谱分析法测定NO的含量 ,用放射免疫法测定ET的含量。结果 :偏头痛患者急性发作期血浆NO和ET含量均显著高于正常对照组 (P <0 .0 5) ,偏头痛缓解期血浆NO降低 ,与对照组比较无显著差异(P >0 .0 5)。血浆ET含量也降低 ,但仍高于正常对照组 (P <0 .0 5)。急性发作期血浆NO和ET含量呈显著正相关 (r=0 .564,P <0 .0 1 )。还发现偏头痛患者急性发作期血浆NO和ET比值较对照组降低 (P <0 .0 5) ,而缓解期较对照组增高 (P <0 .0 5)。结论 :偏头痛患者可能存在血浆NO和ET的动态失衡 。

Objective:To study the roles of nitric oxide (NO) and endothelin (ET) in the pathogenesis of migraine without aura. Methods:Using RIA and HPLC, the plasma levels of NO and ET were measured in patients with migraine with 40 age matched normal subjects as control. Results: The plasma levels of ET and NO in headache attack periods were significantly higher than those during headache free periods, and those of controls (both P <0.05). The plasma ET level during headache free periods was higher than that of controls ( P <0.05).the differences of NO levels between headache free periods and controls was not significant ( P >0.05).ET/No ratio in headache attack periods was lower than that of controls ( P <0.05),but the ET/NO ratio during headache free periods was higher than that of controls ( P <0.05). Conclusion: The results suggested that the changes of ET/NO might played important role in the pathogenesis of migraine.