胃肠胰神经内分泌肿瘤诊治理念更新与焦点问题

Renewal of ideas and focus of gastroenteropancreatic neuroendocrine neoplasm

胃肠胰神经内分泌肿瘤(GEP-NENs)的发病率逐年增加,在这类肿瘤的诊治过程中,应充分重视多学科合作和建立区域诊治中心的重要性。改善生活质量、延长存活期和控制激素过量分泌的相关症状是神经内分泌肿瘤治疗的主要目标。这一领域仍有许多尚待解决的焦点问题,如准确的病理分级和分期、发现诊断和治疗的分子靶标、什么是适宜的治疗顺序和疗效评价手段、是否所有的神经内分泌瘤都需要治疗等,这些问题的解决有助于改善GEP-NENs的治疗效果。

The incidence of gastroenteropancreatic neuroendocrine neoplasm （GEP-NENs） is increasing. More emphasis should be paid to the muhidisciplinary cooperation and construction of regional center of excellence. The goals of treatment for GEP-NENs are improving quality of life, prolonging survival and control of symptom related to excessive hormone secretion. There are still lots of problems need to be solved in this field, such as accurate pathological grade and stage, molecular target for diagnosis and treatment, proper treatment sequence and evaluation criteria, and whether all neuroendocrine tumor need to be treated. The answers to these questions will improve the outcome of GEP-NENs.