肝内胆管癌的临床病理特征、诊断与治疗

THE CLINICO-PATHOLOGIC FEATURES, DIAGNOSIS AND THERAPY FOR THE INTRAHEPATIC CHOLANGIOCA-CINOMA

目的 探讨肝内胆管癌的临床病理特征及治疗与预后的关系。方法 综述近年来肝内胆管癌有关概念、病因与病理、临床与影像学诊断、治疗与预后的文献资料。结果 肝内胆管癌比肝细胞癌少见且预后不良 ,可分为包块型、胆管周围浸润型与胆管内生长型 ,主要沿Glisson’s鞘、淋巴管及门静脉播散 ,影像学诊断很重要 ,手术切除是理想治疗 ,影响预后的因素是无瘤边缘、淋巴结转移与组织病理情况。

Objective To explore clinical-pathologic features and relation between treatment and prognosis for intrahepatic cholangiocarcinoma (IHCC). Methods Literatures about etiology, pathology,clinical and imaging diagnosis,treatment and prognosis for IHCC were reviewed. Results IHCC was a relatively rare cancer and with unfavourable prognosis little is known about its etiology, clinical or pathogical features. IHCC was classi fied as mass-forming, periductal infitrating and intraductal growth types, which had a tendency to spread along Glisson's sheath, lymphatic vessels and portal vein system. Imaging diagnosis is very essential, surgery was the optimal therapy. Factors influencing survival after hepatectomy were tumor free margin, lymphonodes metastasis and histopathology of tumors.Conclusion Active resective therapy is the most effective procedures.