肿瘤相关中性鞘糖脂的实验研究

INVESTIGATION ON TUMOR ASSOCIATED NEUTRAL GLYCOSPHINGOLIPIDS

为了探讨中性鞘糖脂与肿瘤发生、抗原调控、免疫逃避的关系 ,实验系统研究了中性鞘糖脂在胚胎及肿瘤组织中的表达规律及临床意义 ,分析了正常及异常表达的鞘糖脂对肿瘤细胞生长调控、免疫逃避和多药耐药的影响。发现了肿瘤胚胎相关抗原CDH、肿瘤耐药相关中性鞘糖脂CMH和肿瘤抑制因子Globoside ;揭示了抑制糖脂合成及去N 糖基化在逆转肿瘤耐药和肿瘤治疗中的重要意义。

To investigate the roles of neutral glycosphingolipids (N-GSLs) in the development of tumor, tumor antigen expression and immunological evasion, the regularities of the expression of N-GSLs in human embryonic and neoplastic tissue were studied, the influence of N-GSLs in the growth regulation, immunological evasion and multidrug resistance(MDR) of tumor cells were analyzed. The tumor embryonic associated antigen CDH, tumor multidrug resistance associated N-GSLs CMH and neoplasm inhi-bitor globoside were found. The significance of N-GSLs synthesis inhibition and de-N-glycosylation in the reversion of MDR and tumor therapy was also partly disclosed.