摘要
目的:研究天然冰片对雄性SD大鼠口服尼莫地平药代动力学的影响。方法:大鼠随机分为3组:对照组、天然冰片临床等效剂量组(90 mg·kg-1)及高剂量组(270 mg·kg-1),在灌胃给予空白溶媒或天然冰片后各组均口服尼莫地平20 mg·kg-1,于给药前和给药后不同时间点取血,样品处理后用液相色谱-串联质谱(LC-MS-MS)法测定尼莫地平含量,采用WinNonlin 5.0.1计算药代动力学参数。结果:临床等效剂量的天然冰片对尼莫地平口服吸收无显著影响,高剂量天然冰片使血浆中尼莫地平的浓度-时间曲线下面积(AUC)增大,但与对照组间的差异无统计学意义。结论:高剂量天然冰片可轻微促进尼莫地平的口服吸收,但影响较小。
Objective: To study the effects of natural borneol (NB) on the pharmacokinetics of nimodipine in rats after oral administration. Method: The rats were randomly divided into three groups, control group, clinically-equivalent-dose group and higher-dose group, and were gavaged with NB at doses of 0, 90, 270 mg ·kg-1, respectively. After l0 min, all rats were gavaged with nimodipine at a dose of 20 mg·kg-1. The blood was obtained at different time points before and after the administration. Concentrations of nimodipine in plasma were determined by LC-MS-MS and the main pharmacokinetic parameters were calculated by WinNonlin 5.0. 1. Result: Clinically equivalent dose of NB showed little influence on the pharmaeokinetics of nimodipine. The mean value of AUC in higher-dose group was slightly higher than that in control group, but no significant differences were found between two groups. Conclusion: The results suggested that higher dose of NB may enhance the absorption of nimodipine in rats, but the enhancing effect is not very obvious.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第12期128-132,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81173564,81274028)
中山大学青年教师培育项目(2010060)