美沙酮维持治疗者合丙肝患者的HCV-RNA定量与ALT检测结果分析

THE ANALYSIS OF HCV-RNA QUANTIFICATION AND ALT TEST AMONG METHADONE MAINTENANCE TREATMENT PATIANTS WITH HEPATITIS C VIRUS INFECTION

目的:了解美沙酮维持治疗者合并丙型病毒性肝炎者HCV-RNA定量与ALT的检测情况,以明确在该人群中丙肝病毒复制、传染程度及需要治疗人数比例。方法:采集53例美沙酮维持治疗者合并丙肝患者的血液样本进行HCV-RNA定量与ALT检测,并对检测结果进行分析。结果:美沙酮维持治疗者合并丙肝患者53例中HCVRNA定量检测结果的异常率为77.36%(41/53);ALT异常率73.58%(39/53);HCV-RNA定量异常者并存ALT异常比例为87.80%(36/41),HCV-RNA定量正常者ALT异常率为25.00%(3/12),两者比较有统计学差异(χ2=18.838,P<0.01)。结论:美沙酮维持治疗者合并丙肝患者当中丙肝病毒复制活跃、传染程度高及需要治疗人数比例高,增加了丙肝传播风险和社会负担等社会公共卫生问题,建议政府完善对该人群现存丙肝的防控措施和政策。

Objective：To explore the situation of test of HCV - RNA and ALT among the MMT patients with hepatitis C, and then to understand the replication of hepatitis C virus, the degree of infection and the proportion of patients who need treatment. Methods： Fifty - three cases were collected and analyzed by HCV- RNA quantitative and ALT tests. Results：77.36% and 73.58% of the cases were thought as abnormal by HCV - RNA quantitative test and ALT test, respectively. There are 87.80% （36/41）of the patients with abnormal HCV -RNA quantitative suffered from abnormal ALT, and only 25.00% （3/12）of the patients with normal HCV -RNA quantitative suffered from abnormal ALT（x^2 = 18. 838,P 〈0.01 ）. Conclusion：The replication of hepatitis C virus is active among the MMT patients, and the degree of infection is high, so many patients need relative treatment. The situation increased the risk of transmission of hepatitis C and social burden, suggesting a necessity for improvement of the prevention and treatment of hepatitis C virus among MMT.