摘要
目的 :探讨药用植物红景天提取物——红景天素 ( Rhodosin)抗老化和抗痴呆效应。方法 :采用大鼠跳台、水迷宫实验 ,测定海马内乙酰胆碱 ( Ach)含量及胆碱乙酰转移酶 ( Ch AT)活性和脑组织内LPO含量、SOD活性 ,同时对海马神经细胞进行结构状态及超微结构观测。结果 :红景天素对大鼠的学习记忆障碍有明显的改善作用 ,能增强海马中 Ach含量及 Ch AT活性 ,降低脑组织 LPO含量 ,增强SOD活性 ,阻抑大脑、海马的锥体细胞细胞器的退行性变化。结论 :红景天素对老龄大鼠有明显抗老化作用 ,对阿尔茨海默病 ( Alzheimer′s disease,AD)模型鼠具有防治、保护和抗痴呆效应。
Objective:To discuss the effects of Rhodosin,the extractant of medical plants named Rhodiola Sachinonsis A.Bor,on aging rats and the model rats of Alzheier′s disease (AD).Methods:Step down and water maze tests were used to determine the content of acetylcholine (Ach) and the activity of acetylcholine transferase (ChAT) of hippocampus,lipid peroxide (LPO) and activity of superoxide dismute (SOD) of the cerebral cortex,and cerebellar cortex and spinal cord were observed respectively.At the same time,the general light microscope and eletron microscope were used to observe the changes in morphology.Results:The Rhodosin as an antioxidant could enhance the content of Ach and the activity of ChAT,reduce the formation of LPO,and increase activity of SOD.The Rhodosin could facilitate metabolism,enhance activity,and inhibit degeneration of aging rat cells.Conclusion:Rhodosin had obvious anti-aging effects on aing rats and also had preventive,protective,anti-dementia effects on experimental dementia.[
出处
《白求恩医科大学学报》
CAS
CSCD
北大核心
2001年第2期127-129,共3页
Journal of Norman Bethune University of Medical Science
基金
吉林省科委资助!项目 (970 5 5 9- 3)
