摘要
目的 :观察左旋氨氯地平对自发性高血压大鼠 ( SHR)血压和心率以及麻醉犬血压的影响。方法 :经灌胃给药后用 RBP- 1型大鼠血压计测量 SHR血压和心率 ;经十二指肠给药后用 RM- 60 0 0型多导记录仪测量麻醉犬血压。结果 :左旋氨氯地平能明显降低 SHR血压和心率 ,能降低麻醉犬血压 ,与氨氯地平的作用相近。结论 :左旋氨氯地平具有确切的降压作用。
Objective:To compare the antihypertensive effect of L-amloipine with that of amlodipine. Methods :Blood pressure and heart rate of SHRs were measured with blood pressure meter of rat (SBP-1) by administrating L-amlodipine and amlopdipine through mouth.Hemodynamic parameter of anaesthetic dogs was determined by administrating drugs through duodenum with Polygraph System (RM6000). Results:L-amlodipine could slowly reduce the blood pressure and heart rates of clearing SHRs,it could also reduce the blood pressure of normal anaesthetic dogs and the action of L-amlodipine was similar to that of amlodipine. Conclusion:L-amlodipine as a new antihypertensive drug can significantly reduce blood pressure. [
出处
《白求恩医科大学学报》
CAS
CSCD
北大核心
2001年第2期132-134,共3页
Journal of Norman Bethune University of Medical Science