左旋氨氯地平对自发性高血压大鼠血压和心率以及麻醉犬血压的影响

Antihypertensive effect of L-amlodipine in SHRs and anaesthetic dogs

目的 :观察左旋氨氯地平对自发性高血压大鼠 ( SHR)血压和心率以及麻醉犬血压的影响。方法 :经灌胃给药后用 RBP- 1型大鼠血压计测量 SHR血压和心率 ;经十二指肠给药后用 RM- 60 0 0型多导记录仪测量麻醉犬血压。结果 :左旋氨氯地平能明显降低 SHR血压和心率 ,能降低麻醉犬血压 ,与氨氯地平的作用相近。结论 :左旋氨氯地平具有确切的降压作用。

Objective:To compare the antihypertensive effect of L-amloipine with that of amlodipine. Methods :Blood pressure and heart rate of SHRs were measured with blood pressure meter of rat (SBP-1) by administrating L-amlodipine and amlopdipine through mouth.Hemodynamic parameter of anaesthetic dogs was determined by administrating drugs through duodenum with Polygraph System (RM6000). Results:L-amlodipine could slowly reduce the blood pressure and heart rates of clearing SHRs,it could also reduce the blood pressure of normal anaesthetic dogs and the action of L-amlodipine was similar to that of amlodipine. Conclusion:L-amlodipine as a new antihypertensive drug can significantly reduce blood pressure. [