莨菪碱注射液辅助阿奇霉素序贯疗法在小儿支原体肺炎治疗中的应用分析

Analysis on the application of anisodamine injection assisted azithromycin sequential therapy in the treatment of children with mycoplasma pneumonia

目的:探讨山莨菪碱注射液辅助阿奇霉素序贯疗法治疗小儿支原体肺炎的临床疗效及安全性,为临床用药提供依据。方法:选择2010年4月-2013年4月某院收治的126例小儿支原体肺炎患儿,随机分为观察组与对照组,每组63例。对照组采用阿奇霉素序贯疗法治疗,观察组在对照组的基础上,给予山莨菪碱肺腧穴注射,连续治疗8 d,观察2组患儿临床疗效,并记录小儿支原体肺炎主要症状消失时间及不良反应发生情况。结果:观察组患儿咳嗽、气喘、发热小儿支原体肺炎主要症状消失时间明显短于对照组(P<0.05);观察组显效33例,有效29例,无效1例,总有效率98.41%,对照组显效28例,有效26例,无效9例,总有效率85.71%,2组患儿总有效率差异有统计学意义(P<0.05);观察组平均住院时间(6.9±2.8)d,对照组(8.6±3.1)d,观察组短于对照组(P<0.05);观察组治疗前后全血低切黏度、血浆黏度、血小板聚集率等指标差异有统计学意义(P<0.05)。结论:采用山莨菪碱注射液辅助阿奇霉素序贯疗法治疗小儿支原体肺炎临床效果明显,住院时间短,安全性好,值得在临床上推广应用。

OBJECTIVE To investigate the clinical efficacy and safety of anisodamine injection assisted azithromycin sequen- tial therapy in the treatment of children＇s mycoplasma pneumoniae, providing an objective basis for clinical medication, METH- OIlS 126 cases of children with mycoplasma pneumonia from April 2010 - April 2013 in our hospital were selected and ran- domly divided into two groups, the observation group and control group, 63 cases of each group. Control group using azithro- mycin sequential therapy, observation group were given anisodamine lung acupoints injection based on control group, continu- ous treatment for eight days. Clinical efficacy was observed in patients, recording the time of disappearance of main symptoms of mycoplasma pneumonia and the occurrence of adverse reactions. RESULTS The disappearance time of cough, wheezing, fe- ver, mycoplasma pneumonia main symptoms in observation group was significantly shorter than that in the control group （P〈 0. 05） in observation group, 33 cases were markedly effective, 29 cases effective, 1 case invalid, the total efficiency rate was 98. 41 %; in the control group, 28 cases were markedly effective, 26 cases effective, 9 cases invalid, the total efficiency was 85.71 %, there was statistically significant difference in total efficiency between the two groups of children （P〈0. 05） in ob- servation group, the average hospitalized time was （6. 9 ± 2. 8） d, the control group （8. 6 ± 3.1） d it was significant shorter in observation group than in the control group （P〈0. 05）. In observation group, as compared with before treatment the whole blood low shear viscosity, plasma viscosity, platelet aggregation rate were improved significantly after treatment （P〈0. 05）. CONCLUSION The clinical efficacy of anisodamine injection assisted azithromycin sequential therapy for mycoplasma pneu- moniae was obvious, and it also had the advantages of shorter hospitalized time and good safety, so it is worthy to be widely used in clinical.