宫内感染早期诊断

Early diagnosis of intrauterine infection

临床上,宫内感染的早期发现、早期预防及治疗对改善母儿预后至关重要。目前常用的诊断方法使许多亚临床感染的孕产妇得不到及时诊治而错失最佳干预时机。研究证实,羊水白细胞计数、C-反应蛋白、白介素-6、白介素-8、基质金属蛋白酶-8等对宫内感染有一定的预测价值,而蛋白质组学的发展则为早期有效诊断羊膜腔炎症创造了机遇。

Prompt and accurate diagnosis of intrauterine infection in the early stage of the disease is critical for improved maternal and neonatal outcomes. However, diagnosis of intrauterine infection is challenging because most infections are subclinical and clinically relevant biomarkers are critical to the accurate diagnostic of intrauterine infection. Recently, the related studies reveal that indicators such as white blood cell counts, C-reactive protein, interleukin-6, interleukin-8,matrix metalloproteinases-8 and so on may have the certain predictive value of intra-amniotic infection. Also, the development of proteomics has created an opportunities for the advanced diagnosis of intrauterine infection effectively and promptly.