氟化牛奶中氟的生物利用率研究

A study on the bioavailability of fluoride added into milk

目的 观察氟化牛奶中氟的生物利用率。方法 运用药物代谢动力学的方法及交叉对照的实验方法 ,观察了 8名受试者分别饮用氟化牛奶和氟水后血氟及尿氟水平的变化。结果 血药浓度法测得氟化牛奶中氟的生物利用率为 80 2 % ,尿药浓度法测得氟化牛奶中氟的生物利用率为84 8% ,与氟水相比约低 2 0 0 %。

Objective To assess the bioavailability of fluoride added into milk Methods Eight subjects were studied by testing fluoride levels in blood and urine samples collected after drinking fluoridated milk and fluoridated water respectively, according to pharmacokinitics and cross control method Results The bioavailability of fluoride in fluoridated milk reached 80 2% in blood analysis and 84 8% in urine analysis The result was about 20 0% lower as compared with fluoridated water Conclusion Fluoride bioavailability in fluoridated milk is still high and sufficient