妊娠高血压疾病母血及脐血神经功能及抗氧化能力相关指标的变化

Change of maternal blood and umbilical blood nerve function and antioxidant capacity related indexes of patients with hypertensive disorder complicating pregnancy

目的:观察妊娠高血压疾病母血及脐血神经功能及抗氧化能力相关指标的变化情况。方法:选取本院收治的56例妊娠高血压疾病孕妇为观察组,并以同期的56例健康孕妇为对照组,将两组的母血及脐血神经功能及抗氧化能力相关指标进行检测与比较,并比较观察组中轻度、中度及重度妊娠高血压患者的上述指标检测结果。结果:观察组的母血及脐血总抗氧化能力(TAC)、谷胱甘肽过氧化物酶(GSH-Px)及基质金属蛋白酶-9(MMP-9)、脑源性神经营养因子(BDNF)均低于对照组,而母血及脐血血清过氧化脂质(LPO)及血浆神经元特异性烯醇酶(NSE)则高于对照组,同时轻度、中度及重度者之间比较,差异具有统计学意义(P<0.05)。结论:妊娠高血压疾病母血及脐血神经功能及抗氧化能力相关指标均呈现异常的状态,且轻度、中度及重度者之间也有明显差异。

Objective. To study and observe the changes of maternal blood and umbilical blood nerve function and antioxidant capacity related indexes of patients with hypertensive disorder in pregnancy. Methods.A total of 56 pregnant women with hypertensive disorder complicating pregnancy in our hospital from January 2012 to October 2013 were enrolled as observation group, 56 healthy pregnant women were selected as control group. Then the maternal blood and umbilical blood nerve function and antioxidant ca- pacity related indexes of two groups were detected and compared, and those detection indexes of patients with mild, moderate and severe hypertensive disorder complicating pregnancy were compared too. Results. TAC, GSH-Px, MMP-9 and BDNF in both maternal blood and umbilical blood were all lower than those of control group, while LPO and NSE of the maternal blood and umbilical blood were higher than those ofcontrol group. Besides, the detected levels of patients with mild, moderate and severe hypertensive disor- der complicating pregnancy were significantly different too （P〈0.05）. Conclusion. The maternal blood and umbilical blood nerve function and antioxidant capacity related indexes of patients with hypertensive disorder complicating pregnancy are abnormal, and the detected levels are significant different among pa- tients with mild, moderate and severe disease.