潮汕地区健康人群甲胎蛋白参考值调查

Investigation of AFP reference value of healthy population in Chaoshan area

目的建立潮汕地区健康成人血清甲胎蛋白（AFP）的临床参考范围。方法随机采集潮汕地区2011—2013年健康体检者9236人，其中男性5600人，女性3636人，年龄在18～80岁。采用全自动化学发光免疫检测系统（德国西门子ADVIAcentaur）对AFP定量分析。以百分位数法（≤P95）计算血清AFP的参考范围。采用软件PASW18．0进行统计分析。结果健康成年人血清AFP参考范围性别差异有统计学意义（P〈0．01）；且男、女血清AFP浓度均随着年龄增加而显著升高，各年龄段差异有统计学意义（P〈0．01）。结论潮汕人群血清AFP浓度按年龄及性别分组建立的参考范围更加合理、确切。

Objective To establish the AFP reference value of healthy adults in Chaoshan area. Methods A total of 9 236 healthy adults including 5 600 men and 3 636 women aged from 18 to 80 years were enrolled in Chaoshan area from 2011 to 2013. The concentrations of AFP were detected by the automatic chemil immunodetection system （Siemens ADVIA centaur）, and the results were analyzed statistically by PASW 18.0. Results The AFP reference value had a statistical difference between men and women （P 〈0.01）, and the serum AFP concentrations were increased with the age （ P 〈 0.01 ）. Conclusions It is more accurate to establish the serum AFP reference value depending on the sex and age in Chaoshan adults.