关联负变化与血管性痴呆患者认知障碍的关系

Vascular Dementia and Contingent Negative Variation

目的 探讨血管性痴呆 (vasculardementia,VD)患者关联负变化 (contingentnegativevariation ,CNV)的特点。方法 对 2 4例VD患者及 2 2例正常老年人进行CNV测试和比较。结果 VD患者CNV的早成分M1、晚成分M2 的潜伏期均较正常人明显延长 ,且与认知障碍程度密切相关 ;M1的波幅降低 ;反应时间 (reactivetime ,RT)延长 ,且与认知障碍程度密切相关 ;典型的命令信号后负变化 (postimperativenegativevariation ,PINV)出现率增多。结论 CNV值可用于反映VD患者的痴呆程度 。

Purpose: To study the characteristics of contingent negative variation (CNV) in vascular dementia. Methods: CNV was tested and compared in 24 vascular dementia (VD) patients and 22 normal aged persons. Results: The data showed that in compare with normal controls the latencies of early component and late component of CNV in VD were greatly prolonged and closely correlated to the extent of dementia. The amplitude of early component was greatly reduced. The reactive time (RT) was prolonged prominently and also correlated with the extent of dementia. The occurrence of postimperative negative variation (PINV) increased. Conclusions: The value of CNV can be used to reflect the extent of dementia. Test the CNV in series may help to evaluate the cognitive impairment in VD.