血清HA、PCⅢ和PCⅣ联合检测评估肝纤维化的临床病理价值

Clinical and Pathological Value of Serum Hyaluronate Acid,Type Ⅲ Procollagen and Type Ⅳ Procogen for Predicting Liver Fibrosis

目的 寻求反映肝纤维化的无创性检查。方法 联合检测 48例各种类型的肝病血清Ⅲ前胶原 (serumtypeⅢ procollagen ,PCⅢ )、透明质酸 (hyaluronateacid ,HA)、血清Ⅳ型胶原 (serumtypeⅣ procogen ,PCⅣ ) ,并与其肝组织病变对照研究。结果 显示血清HA、PCⅢ和PCⅣ水平在慢性肝炎轻度、中度、重度和重型肝炎呈现进行性升高。血清HA、PCⅢ和PCⅣ随肝组织炎症活动指数和肝组织纤维化程度加重而升高。结论 若能去除炎症因素的影响 。

Purpose To establish sensitive and reliable serum marker on liver fibrosis for early clinical diagnosis. Methods Serum hyaluronate acid,type Ⅲ procollagen and type Ⅳ procogen of 48 patients with viral hepatitis were analyzed by radioimmunoassay and ELISA respectively. Results The serum HA,PCⅢ and PCⅣ level increased gradually with the progress of the disease.Their levels were correlated distinctly with the index of hepatic activity of inflammation and that of fibrosis. Conclusions The value of serum HA,PCⅢ and PCⅣ in predicting liver fibrosis will be enhanced if the effect of inflammation could be excluded.