阻断肾素-血管紧张素-醛固酮系统对慢性充血性心衰大鼠心功能的影响

Changes of Cardiac Function in CHF rats after Blocking the Renin-Angiotensin-Aldosterone System at Different Sites

目的 观察阻断RAAS的不同环节对心衰大鼠心功能的影响。方法 2 6周龄的SD大鼠心梗后 6周建立充血性心衰模型 (n =6 6 ) ,随机分 4组 ,分别用苯那普利、安体舒通、氯沙坦、安慰剂治疗 ,另以假扎组为正常对照 (n =18) ,治疗 6周后分别测定左室血流动力学指标。结果 4组治疗组与假扎正常对照组比较 ,左室舒张末压 (LVEDP)均显著增加 ,左室收缩压峰值 (LVPSP)、左室压力最大上升和下降速率 (±dp/dtmax)绝对值显著低(P <0 .0 5 )。 3组药物治疗组与安慰剂治疗组比较 :苯那普利治疗组和氯沙坦治疗组的死亡率降低 ,LVEDP降低 ,LVPSP、±dp/dtmax绝对值增加 (P <0 .0 5 ) ;安体舒通治疗组各指标无著差异。结论 苯那普利和氯沙坦可减缓充血性心力衰竭的心功能恶化 ,降低死亡率 ;安体舒通虽无保护心功能的作用 。

Purpose: To observe the effects of blocking the renin-Angiotensin-Aldosterone system at different sites in experimental congestive heart failure (CHF) rats. Methods: Six weeks after coronary ligation, rats (n = 66) were randomized to benalapril, losartan, spironolactone, placebo, and treated for 6 weeks. Sham-operated rats (n = 18) served as controls. Six weeks later left ventricular hemodynamics were measured. Results: In the hemodynamic variables, HR was not significantly different between groups. Compared four treatment groups with sham-operated group, LVEDP increased, LVPSP and ± dp/dtmax decreased (P max in benalapril group and in losartan group increased (P < 0.05). Conclusions: Administration of ACEI and AgII-AT1 antagonist are effective in preventing from cardiac function deterioration, while spironolactone treatments are not. Spironolactone has tendency in decreasing LVEDP.